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Author Notes:

Address correspondence to: Peng Jin, Ph.D., Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA 30322. Email: peng.jin@emory.edu

The authors would like to thank C. Strauss for critical reading of the manuscript.

No competing financial interests exist.

Subjects:

Research Funding:

H.I. is supported by the Training Program in Human Disease Genetics funded by NIH (T32MH087977).

P.J. is supported by NIH grants (NS051630, MH076090, and P50AG025688).

Dynamics of DNA Methylation in Aging and Alzheimer's Disease

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Journal Title:

DNA and Cell Biology

Volume:

Volume 31, Number Suppl 1

Publisher:

, Pages S-42-S-48

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Gene expression is modulated by epigenetic factors that come in varying forms, such as DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent studies reveal that these epigenetic marks are important regulatory factors in brain function. In particular, DNA methylation dynamics are found to be essential components of epigenetic regulation in the mammalian central nervous system. In this review, we provide an overview of the literature on DNA methylation in neurodegenerative diseases, with a special focus on methylation of 5-position of cytosine base (5mC) and hydroxymethylation of 5-position of cytosine base (5hmC) in the context of neurodegeneration associated with aging and Alzheimer's disease.

Copyright information:

© 2012, Mary Ann Liebert, Inc.

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