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Author Notes:

Corresponding author: Theresa W. Gauthier, MD, Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Emory University, 2015 Uppergate Drive NE, Atlanta, GA 30322; Phone: (404) 727-3360 Fax: 404-727-3236; tgauthi@emory.edu


Research Funding:

Supported in part by PHS Grant (TL1 RR025010) from the Clinical and Translational Science Award program, National Institutes of Health, National Center for Research Resources (KRS) and the Childrens Healthcare of Atlanta Center for Developmental Lung Biology (TWG and LAB).


  • cytokines
  • chronic lung disease
  • premature neonate

Inflammatory mediator patterns in tracheal aspirate and their association with bronchopulmonary dysplasia in very low birth weight neonates


Journal Title:

Journal of Perinatology


Volume 33, Number 5


, Pages 383-387

Type of Work:

Article | Post-print: After Peer Review


Background Alterations in inflammatory mediators are an important finding in neonates who develop bronchopulmonary dysplasia (BPD); however, there is a lack of research examining the relationship between multiple inflammatory mediators in premature neonates and the development of BPD. Objective This study investigated whether the distribution of 12 inflammatory mediators detected in the tracheal aspirate (TA) of neonates within 24 hours of birth could differentiate between neonates who did and did not develop BPD. Study Design TA samples were collected from 27 very low birth weight neonates (BPD+ =11) and the concentrations of 12 biomarkers associated with BPD were determined. Linear discriminate analysis (LDA) was used to classify neonates into two outcome groups. Result LDA based on the 12 measured biomarkers displayed a significant level of discriminant function (p=0.007). Conclusion Using linear discriminant analysis, predictive models of BPD can be generated. Our results suggest that multiple inflammatory mediators collected within 24 hours of birth may be used to classify neonates into who will and will not develop BPD.

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© 2012, Rights Managed by Nature Publishing Group

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