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Author Notes:

Corresponding author: Judith Eisen, Institute of Neuroscience, 1254 University of Oregon, Eugene OR 97403. Phone: 541-346-4524; Fax: 541-346-4548; Email: eisen@uoneuro.uoregon.edu

Thanks to Robert Kelsh, Dave Raible and Ken Wallace for critical reading of manuscript drafts.

We thank our many colleagues for discussions of ENS development and apologize to any of them whose work was inadvertantly left out of this review.

Subjects:

Research Funding:

Our original research on the ENS is supported by NIH HD22486 (JE) and DK067285 (IS).

Development of the Zebrafish Enteric Nervous System

Tools:

Journal Title:

Methods in Cell Biology

Volume:

Volume 101

Publisher:

, Pages 143-160

Type of Work:

Article | Post-print: After Peer Review

Abstract:

The enteric nervous system is composed of neurons and glia that modulate many aspects of intestinal function. The ability to use both forward and reverse genetic approaches and to visualize development in living embryos and larvae has made zebrafish an attractive model in which to study mechanisms underlying enteric nervous system development. Here we review recent work describing the development and organization of the zebrafish enteric nervous system and how this relates to intestinal motility. We also discuss the cellular, molecular and genetic mechanisms that have been revealed by these studies and how they are providing new insights into human enteric nervous system diseases.

Copyright information:

© 2011 Elsevier

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