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Author Notes:

Correspondence: Shanthi Srinivasan, MD, Division of Digestive Diseases, Emory University, Whitehead Research Building, Suite 246, 615 Michael St., Atlanta, GA 30307, USA; Email: ssrini2@emory.edu; Phone: 404-727-5298

Disclosures: No potential conflict of interest relevant to this article was reported.


Research Funding:

This work was supported by the following grants: National Institutes of Health DK080684 (Dr. Srinivasan) and Veterans Administration Merit award (Dr. Srinivasan).


  • Enteric nervous system
  • Small intestine
  • Neurotransmitters
  • Intestinal secretion
  • Irritable bowel syndromes
  • Inflammatory bowel disease
  • Diabetes mellitus

Enteric Nervous System in the Small Intestine: Pathophysiology and Clinical Implications


Journal Title:

Current Gastroenterology Reports


Volume 12, Number 5


, Pages 358-365

Type of Work:

Article | Post-print: After Peer Review


The digestive system is endowed with its own, local nervous system, referred to as the enteric nervous system (ENS). Given the varied functions of small intestine, its ENS has developed individualized characteristics relating to motility, secretion, digestion, and inflammation. The ENS regulates the major enteric processes such as immune response, detecting nutrients, motility, microvascular circulation, intestinal barrier function, and epithelial secretion of fluids, ions, and bioactive peptides. Remarkable progress has been made in understanding the signaling pathways in this complex system and how they work. In this article, we focus on recent advances that have led to new insights into small intestinal ENS function and the development of new therapies.

Copyright information:

© Springer Science+Business Media, LLC 2010

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