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To whom correspondence should be addressed. For S.F.T.: Phone, +1-404-727-0357; Fax, +1-404-727-0365; strayne@emory.edu. For J.P.S.: Phone, 404-727-2415; Fax, +1-404-727-6586; jsnyder@emory.edu
Department of Chemistry, Emory University.
Department of Pharmacology, Emory University School of Medicine.
Department of Neurobiology, Duke University.
FOB Synthesis, Inc., Emtech Bio (Emory University and Georgia Tech).
Several of the authors (Y.A.T., J.P.S., D.L., R.D., S.F.T., J.O.M.) are inventors of Emory University owned patent-pending technology associated with these compounds, or have an equity position in companies actively seeking to license these compounds (JPS, DL, RD, SFT)
We thank Drs. Elias Aizenman, Stephen Heinemann, Shigetada Nakanishi, Pierre Paoletti, and Peter Seeburg for sharing cDNA for glutamate receptors and mutants, and Dr. Mark Washburn for assistance in several of the biological assays.
We are also grateful to OpenEye Scientific Software (Santa Fe, NM) for the generous provision of a no-cost license to use software for the conformational analyses described.
This work was supported by NIH-NINDS (NS036654, NS039419 S.T.), NARSAD (S.T.), NIH-NINDS (NS036604, R.D.), NIH-NINDS NS056217 (J.O.M.), the Michael J. Fox Foundation (S.T.), and Parents Against Childhood Epilepsy, Inc. Research Grant Program (R.D.).
© 2008 American Chemical Society