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Research Funding:

National Institute of General Medical Sciences : NIGMS

We appreciate the financial support provided by the National Institutes of Health (GM 059384) and the National Science Foundation (CHE-0450779).

Application of the Rh(ll)-Cyclization/Cycloaddition Cascade for the Total Synthesis of (±)-Aspidophytine


Journal Title:

Organic Letters


Volume 8, Number 15


, Pages 3275-3278

Type of Work:

Article | Post-print: After Peer Review


A new strategy for the synthesis of (±)-aspidophytine has been developed and is based on a Rh(ll)-catalyzed cyclization/dipolar-cycloaddition sequence. The resulting [3+2]-cycloadduct undergoes an efficient Lewis acid mediated cascade that rapidly provides the complete skeleton of aspidophytine. The synthesis also features a mild decarbomethoxylation reaction.

Copyright information:

© 2006 American Chemical Society

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