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Author Notes:

To whom correspondence may be addressed. E-mail: rantia@emory.edu or roland.regoes@env.eth.ch

Edited by Alan S. Perelson, Los Alamos National Laboratory, Los Alamos, NM, and accepted by the Editorial Board November 1, 2006

Author contributions: R. Ahmed and R. Antia designed research; D.L.B. performed research; R.R.R. and R. Antia analyzed data; and R.R.R. and R. Antia wrote the paper.


Research Funding:

This work was supported by National Institutes of Health Grants AI-49334 (to R. Antia) and AI-30048 (to R. Ahmed).

Estimation of the rate of killing by cytotoxic T lymphocytes in vivo


Journal Title:

Proceedings of the National Academy of Sciences


Volume 104, Number 5


, Pages 1599-1603

Type of Work:

Article | Post-print: After Peer Review


Cytotoxic T lymphocytes (CTL) help control virus infections by killing virus-infected (target) cells. How fast do CTL find and kill target cells in vivo? Experiments allow us to follow populations of labeled target cells after their transfer into immune mice where they are killed by CTL. Here, we develop models of the migration and killing processes involved in these experiments and use them to quantitatively analyze the in vivo killing data. These models allow us to estimate the rate constant for killing of target cells by CTL.

Copyright information:

© 2007 by The National Academy of Sciences of the USA

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