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Author Notes:

Correspondence: John Oshinski, Ph.D., 1364 Clifton Rd, Atlanta, GA 30322; Email: jnoshin@emory.edu; Phone: 404-727-5894; Fax: 404-727-3887

Acknowledgments: We would like to thank Dr. Steven Lloyd for providing scanner time at the University of Alabama at Birmingham.

Subjects:

Research Funding:

This study was supported by National Institutes of Health BRP grant HL70531.

Keywords:

  • MRI
  • fluid dynamics
  • coronary artery
  • human
  • CFD

Coronary artery flow measurement using navigator echo gated phase contrast magnetic resonance velocity mapping at 3.0 T

Tools:

Journal Title:

Journal of Biomechanics

Volume:

Volume 41, Number 3

Publisher:

, Pages 595-602

Type of Work:

Article | Post-print: After Peer Review

Abstract:

A validation study and early results for noninvasive, in vivo measurement of coronary artery blood flow using phase contrast magnetic resonance imaging (PC-MRI) at 3.0 Tesla is presented. Accuracy of coronary artery blood flow measurements by phase contrast MRI is limited by heart and respiratory motion as well as the small size of the coronary arteries. In this study, a navigator-echo gated, cine phase velocity mapping technique is described to obtain time-resolved velocity and flow waveforms of small diameter vessels at 3.0 Tesla. Phantom experiments using steady, laminar flow are presented to validate the technique and show flow rates measured by 3.0 Tesla phase contrast MRI to be accurate within 15% of true flow rates. Subsequently, in vivo scans on healthy volunteers yield velocity measurements for blood flow in the right, left anterior descending, and left circumflex arteries. Measurements of average, cross-sectional velocity were obtainable in 224/243 (92%) of the cardiac phases. Time-averaged, cross-sectional velocity of the blood flow was 6.8±4.3 cm/s in the LAD, 8.0±3.8 cm/s in the LCX, and 6.0±1.6 cm/s in the RCA.

Copyright information:

© 2007 Elsevier Ltd. All rights reserved.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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