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To whom correspondence should be addressed. E-mail: david.lynn@emory.edu
Edited by Harry B. Gray, California Institute of Technology, Pasadena, CA, and approved June 26, 2007
Author contributions: J.D., A.K.M., W.S.C., J.A.S., Z.M., R.A.S., K.W., and D.G.L. designed research; J.D., J.M.C., J.E.S., B.T., W.S.C., J.A.S., and K.W. performed research; J.D., J.M.C., A.K.M., J.E.S., B.T., W.S.C., J.A.S., Z.M., R.A.S., K.W., and D.G.L. analyzed data; and J.D., A.K.M., W.S.C., J.A.S., Z.M., K.W., and D.G.L. wrote the paper.
We thank James Lah and Craig Heilman for initial neurotoxicity assays, Yi Xu and Rong Ni for assistance with peptide synthesis and purifications, and C. L. Emerson for AFM instrumentation.
The Stanford Synchrotron Radiation Laboratory is a national user facility operated by Stanford University (Stanford, CA) on behalf of the U.S. DOE, Office of Basic Energy Sciences. The SSRL Structural Molecular Biology Program is supported by DOE, Office of Biological and Environmental Research and by the NIH National Center for Research Resources and Biomedical Technology Program.
AA analysis was performed by the Keck Biotechnology Resource Laboratory at Yale University (New Haven, CT), and ICP-MS was performed at the Chemical Analysis Laboratory at the University of Georgia.
This work was supported by Department of Energy (DOE) Grant ER15377 (to D.G.L.), National Institutes of Health (NIH) National Institute of General Medical Sciences Grant GM42025 (to R.A.S.), NIH Grants AG 023695 and NS 048254 and the R. W. Woodruff Health Sciences Center Fund (to Z.M.), Emory Alzheimer's Disease Center Grant P50 AG025688 (to D.G.L. and Z.M.), and National Science Foundation Grant CHE-0131013 (for CD instrumentation).
© 2007 by The National Academy of Sciences of the USA