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Author Notes:

Correspondence: Marian L. Evatt, MD, MS, Department of Neurology, Emory University School of Medicine, 1841 Clifton Road NE, Atlanta, GA 30329 (Email: mevatt@emory.edu)

Study concept and design: Evatt, DeLong, and Tangpricha.

Acquisition of data: Evatt, Khazai, Rosen, Triche, and Tangpricha.

Analysis and interpretation of data: Evatt, DeLong, and Tangpricha.

Drafting of the manuscript: Evatt and Tangpricha.

Critical revision of the manuscript for important intellectual content: Evatt, DeLong, Khazai, Rosen, Triche, and Tangpricha.

Statistical analysis: Evatt.

Obtained funding: DeLong and Tangpricha.

Administrative, technical, and material support: Evatt, DeLong, Khazai, Rosen, Triche, and Tangpricha.

Study supervision: DeLong and Tangpricha.

We thank the CRIN database participants and the Alzheimer’s Disease Research Center research staff of the Movement Disorders Section, who support the CRIN database.

Financial Disclosure: None reported.

Subjects:

Research Funding:

This study was supported by National Institutes of Health (NIH)/National Center for Research Resources (NCRR) grant K12 RR017643 to the Emory Mentored Clinical Research Scholars Program (M.L.E.), NIH/NCRR grant M01 RR00039 to the Emory General Clinical Research Center (CRIN infrastructure support), NIH grant K23AR054334 (V.T.), NIH/National Institute of Aging grant P50AG025688 to the Emory Alzheimer’s Disease Research Center (A.R.), NIH/National Institute of Environmental Health Sciences grant ES012068 to the Emory University Collaborative Center for Parkinson’s Disease Environmental Research (A.R.), and funds from an anonymous donor.

Prevalence of Vitamin D Insufficiency in Patients With Parkinson Disease and Alzheimer Disease

Tools:

Journal Title:

Archives of Neurology

Volume:

Volume 65, Number 10

Publisher:

, Pages 1348-1352

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Background A role for vitamin D deficiency in Parkinson disease (PD) has recently been proposed. Objective To compare the prevalence of vitamin D deficiency in a research database cohort of patients with PD with the prevalence in age-matched healthy controls and patients with Alzheimer disease (AD). Design Survey study and blinded comparison of plasma 25-hydroxyvitamin D (25[OH]D) concentrations of stored samples in a clinical research database at Emory University School of Medicine. Setting Referral center (PD and AD patients), primary care clinics, and community setting (controls). Participants Participants were recruited into the study between May 1992 and March 2007. Every fifth consecutively enrolled PD patient was selected from the clinical research database. Unrelated AD (n=97) and control (n=99) participants were randomly selected from the database after matching for age, sex, race, APOE genotype, and geographic location. Main Outcome Measures Prevalence of suboptimal vitamin D and mean 25(OH)D concentrations. Results Significantly more patients with PD (55%) had insufficient vitamin D than did controls (36%) or patients with AD (41%; P=.02, χ2 test). The mean (SD) 25(OH)D concentration in the PD cohort was significantly lower than in the AD and control cohorts (31.9 [13.6] ng/mL vs 34.8 [15.4] ng/mL and 37.0 [14.5] ng/mL, respectively; P=.03). Conclusions This report of 25(OH)D concentrations in a predominantly white PD cohort demonstrates a significantly higher prevalence of hypovitaminosis in PD vs both healthy controls and patients with AD. These data support a possible role of vitamin D insufficiency in PD. Further studies are needed to determine the factors contributing to these differences and elucidate the potential role of vitamin D in pathogenesis and clinical course of PD.

Copyright information:

©2008 American Medical Association. All rights reserved.

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