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Author Notes:

dkingston@vt.edu; Fax: +1 540 231 3255; Tel: 1 540 231 6570

We thank Dr Dennis Liotta (Emory University) for support and Dr Gerhard Höfle (Helmholtz HZI, Braunschweig) for a gift of samples of epothilones B and D.

Subject:

Research Funding:

We are grateful for support of this work by NIH Grant CA-69571 and by NSF Grant CHE-0619382 for purchase of the Bruker Avance 600 spectrometer.

Novel Epothilone Lactones by an Unusual Diversion of the Grubbs' Metathesis Reaction

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Journal Title:

Chemical Communications

Volume:

Volume 46, Number 12

Publisher:

, Pages 2019-2021

Type of Work:

Article | Post-print: After Peer Review

Abstract:

An unusual reaction with Grubbs’ catalyst during the synthesis of bridged epothilones yielded five-membered internal lactones instead of the expected metathesis products. Three of the lactones have comparable activities to epothilone D.

Copyright information:

© The Royal Society of Chemistry 2010

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