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Author Notes:

Corresponding Author: Allen D. Beck M.D., Emory Eye Center, 1365-B Clifton Rd, Atlanta GA 30322. Email: abeck@emory.edu. Phone: (404) 778-5416. Fax: (404) 778-4350.

Michael Lynn and Allen Beck had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

There are no proprietary interests to report.

Subjects:

Research Funding:

National Institutes of Health Grants U10 EY13272 and U10 EY013287

NIH Departmental Core Grant EY06360

Research to Prevent Blindness, Inc, New York, New York

Glaucoma-Related Adverse Events in the Infant Aphakia Treatment Study: 1-Year Results

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Journal Title:

Archives of ophthalmology (Chicago, Ill. : 1929)

Volume:

Volume 130, Number 3

Publisher:

, Pages 300-305

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Objective To report the incidence of glaucoma and glaucoma suspects in the Infant Aphakia Treatment Study (IATS). To evaluate risk factors for the development of a glaucoma-related adverse event in IATS in the first year of follow-up. Methods 114 infants with a unilateral congenital cataract were assigned to undergo cataract surgery between 1 to 6 months of age either with (IOL) or without IOL implantation (CL). Standardized definitions of glaucoma and glaucoma suspect were created and used in the IATS. Results Ten patients (9%) developed glaucoma and 4 patients (4%) were glaucoma suspects for a total of 14 patients (12%) with a glaucoma-related adverse event in the treated eye through the first year of follow-up. Five CL patients (9%) and 9 IOL patients (16%) developed a glaucoma-related adverse event. The odds of developing a glaucoma-related adverse event was 3.1 times higher for a child with persistent fetal vasculature (PFV), and 1.6 times higher for each month of age younger at cataract surgery. Conclusions Modern surgical techniques do not eliminate the early development of glaucoma following congenital cataract surgery with or without an intraocular lens. Younger patients with or without PFV seem more likely to develop a glaucoma-related adverse event in the first year of follow-up.Vigilance for the early development of glaucoma is needed following congenital cataract surgery, especially when surgery is performed during early infancy or with PFV. Five year follow-up data for the IATS will likely reveal more glaucoma-related adverse events.

Copyright information:

© 2014 American Medical Association. All Rights Reserved.

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