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Author Notes:

Corresponding author: Karen R Strait, Divisions of Animal Resources, Yerkes National Primate Research Center, Atlanta, Georgia. Email: kstrait@emory.edu.

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Research Funding:

This work was supported by an Investigator-Initiated Study award from Janssen Medical Affairs and a Merit Award from the Office of Research and Development (Department of Veterans Affairs) to ECM and by an NIH/NCRR base grant (P51RR000165) to Yerkes National Primate Research Center.

Chronic, Constant-Rate, Gastric Drug Infusion in Nontethered Rhesus Macaques (Macaca mulatta)

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Journal Title:

Journal of the American Association for Laboratory Animal Science : JAALAS

Volume:

Volume 49, Number 2

Publisher:

, Pages 207-214

Type of Work:

Article | Post-print: After Peer Review

Abstract:

As part of a study of antipsychotic drug treatment in monkeys, we developed a technique to provide chronic, constant-rate, gastric drug infusion in nontethered rhesus macaques. This method allowed us to mimic the osmotic release oral delivery system currently used in humans for continuous enteral drug delivery. Rhesus macaques (n = 5) underwent gastric catheter placement by laparotomy. After the catheters were secured to the stomach, the remaining catheter length was exited through the lateral abdomen, tunneled subcutaneously along the back, and connected to a 2-mL osmotic pump enclosed in a subcutaneous pocket. Osmotic pumps were changed every 2 to 4 wk for 1 y and remained patent for the duration of the study. Four complications (including cutting of the catheter, incisional dehiscence at the pump site, and loss of 1 catheter into the abdominal cavity requiring catheter replacement) occurred among the 80 pump changes performed during the yearlong study. At necropsy, histopathologic examination of the catheter implant sites revealed mild changes consistent with a foreign-body reaction. Our results indicate that the gastric catheter and osmotic pump system was well tolerated in rhesus macaques for as long as 12 mo after placement and suggest that this system will be an attractive option for use in studies that require chronic, constant-rate, gastric drug infusion in nontethered monkeys.

Copyright information:

© American Association for Laboratory Animal Science

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