Predictors of Success with Highly Active Antiretroviral Therapy in an Antiretroviral-Naive Urban Population

• Authors: Elisa Zaragoza-Macias, Emory University; Dominique L. Cosco, Emory University; Minh Ly T Nguyen, Emory University; Carlos Del Rio, Emory University; Jeffrey L Lennox, Emory University
• Journal Title: AIDS Research and Human Retroviruses
• Volume: Volume 26, Number 2
• Publisher: Mary Ann Liebert, Inc. | 2010-02, Pages 133-138
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1089/aid.2009.0001
• Subjects: Health Sciences, Epidemiology

Abstract

Predictors of successful virologic, immunologic, and clinical response with combined antiretroviral therapy (cART) containing a boosted protease inhibitor or a nonnucleoside reverse transcriptase inhibitor were analyzed among an antiretroviral naive (ARV-naive) urban cohort. Measures of success included virologic suppression [HIV-1 viral load (VL) <400 copies/ml], an increase in CD4+ T cells from baseline of >100 cells/μl, and lack of development of an AIDS-defining illness at 24 and 48 weeks after cART initiation. Two hundred and eighty-seven ARV-naive patients were included in this cohort, of which 76.7% were male and 86.8% were nonwhite. At the time of cART initiation their median age was 39 years, the geometric mean CD4+ count was 42 cells/μl, and the mean viral load was 5.3 log10 copies/ml. At 48 weeks, 72% of patients achieved virologic suppression, with ≥90% adherence and high school graduation predicting viral undetectability at 48 weeks. Baseline VL ≤100,000 copies/ml and a CD4+ cell count >100 cells/μl were associated with viral suppression at 24 weeks [OR (95% CI) = 3.55 (1.29–9.81) and 3.96 (1.19–13.15), respectively]; female gender was associated with a greater increase in CD4+ cell counts [OR (95% CI) = 7.41 (2.48–22.1)]. CDC stage A1–C2 at baseline predicted lack of clinical progression at 48 weeks. The results of this analysis of an ARV-naive cohort comprised predominantly of indigent, minority patients suggest that men who did not have a high school education and who had advanced HIV infection are less likely to have therapeutic success after cART initiation.