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Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Emory Briarcliff Campus, Building A, Room 504-N, 1256 Briarcliff Road, NE, Atlanta, GA 30306, USA, Tel: +1 404 712 9770, Fax: +1 404 712 9755, E-mail: cwest@emory.edu


Addendum: Paroxetine-Induced Increase in Activity of Locus Coeruleus Neurons in Adolescent Rats: Implication of a Countertherapeutic Effect of an Antidepressant


Journal Title:



Volume 35, Number 8


, Pages 1836-1837

Type of Work:

Article | Post-print: After Peer Review


In this issue of the journal, we report that paroxetine (PAR), when given to young rats (adolescent age) in moderate doses, produced an increase in electrophysiological activity of locus coeruleus (LC) neurons early in the course of drug administration (West et al, 2010). This effect on LC activity is opposite to the usual decrease in LC activity produced by therapeutic regimens of antidepressant (AD) drug administration (ie, chronic administration of AD drugs). In contrast, the only effects seen in mature adult rats treated with PAR were the usual decreases in LC activity, with no increases seen at any dose or duration of treatment examined. Therefore, the LC response to PAR early in treatment of young animals suggests a countertherapeutic reaction that may relate to an increase in depressive symptomatology, and suicidal ideation in particular, said to occur in some adolescents early in treatment with PAR and other SSRIs.

Copyright information:

© 2010 American College of Neuropsychopharmacology

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