About this item:

784 Views | 0 Downloads

Author Notes:

Corresponding Author: Valérie Biousse, MD Neuro-Ophthalmology Unit. Emory Eye Center. 1365-B Clifton Road NE. Atlanta, GA 30322. Email: vbiouss@emory.edu. Telephone: 404-778-5360. Fax: 404-778-4849.

Subjects:

Research Funding:

This study was supported in part by a departmental grant (Department of Ophthalmology) from Research to Prevent Blindness, Inc., New York, by core grant P30-EY06360 (Department of Ophthalmology).

Dr. Bruce receives research support from the NIH/PHS (KL2-RR025009, UL1-RR025008), NIH/NEI (K23-EY019341), and the Knights Templar Eye Foundation; and received the American Academy of Neurology Practice Research Fellowship.

Dr. Biousse receives research support from NIH/PHS (UL1-RR025008).

Dr. Newman is a recipient of the Research to Prevent Blindness Lew R. Wasserman Merit Award.

Keywords:

  • Idiopathic intracranial hypertension
  • pseudotumor cerebri
  • papilledema
  • cerebral venous stenosis
  • cerebral venous stenting
  • obesity

Update on the pathophysiology and management of idiopathic intracranial hypertension

Tools:

Journal Title:

Journal of Neurology, Neurosurgery and Psychiatry

Volume:

Volume 83, Number 5

Publisher:

, Pages 488-494

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Idiopathic Intracranial Hypertension (IIH) is a disease of unknown etiology typically affecting young, obese women, producing a syndrome of increased intracranial pressure without identifiable cause. Despite a large number of hypotheses and publications over the past decade, the etiology is still unknown. Vitamin A metabolism, adipose tissue as an actively secreting endocrine tissue, and cerebral venous abnormalities are areas of active study regarding IIH’s pathophysiology. There continues to be no evidence-based consensus or formal guidelines regarding management and treatment of the disease. Treatment studies show that the diagnostic lumbar puncture is a valuable intervention beyond its diagnostic importance, and that weight management is critical. However, open questions remain regarding the efficacy of acetazolamide, cerebrospinal fluid shunting procedures, and cerebral transverse venous sinus stenting.

Copyright information:

© 2012 by the BMJ Publishing Group Ltd. All rights reserved

Export to EndNote