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Author Notes:

Address correspondence to Felicia C. Goldstein, Department of Neurology, School of Medicine, Emory University, 1841 Clifton Road, N.E., Atlanta, GA 30329. fgoldst@emory.edu


Research Funding:

Supported by the Emory Alzheimer's Disease Research Center (NIH-NIA 5 P50 AG025688) (AIL).


  • cerebrovascular disease
  • dementia
  • hypertension
  • mild cognitive impairment
  • neuropsychology

High Blood Pressure and Cognitive Decline in Mild Cognitive Impairment


Journal Title:

Journal of the American Geriatrics Society


Volume 61, Number 1


, Pages 67-73

Type of Work:

Article | Post-print: After Peer Review


Objectives To determine whether high blood pressure (BP) levels are associated with faster decline in specific cognitive domains. Design Prospective longitudinal cohort. Setting Uniform Data Set of the National Institutes of Health, National Institute on Aging Alzheimer's Disease Centers. Participants One thousand three hundred eighty-five participants with a diagnosis of mild cognitive impairment (MCI) and measured BP values at baseline and two annual follow-up visits. Measurements Neuropsychological test scores and Clinical Dementia Rating Sum of Boxes (CDR Sum) score. Results Participants with MCI with two or three annual occasions of high BP values (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) had significantly faster decline on neuropsychological measures of visuomotor sequencing, set shifting, and naming than those who were normotensive on all three occasions. High systolic BP values were associated as well with faster decline on the CDR Sum score. Conclusion Hypertension is associated with faster cognitive decline in persons at risk for dementia.

Copyright information:

© 2012, Copyright the Authors, Journal compilation © 2012, The American Geriatrics Society

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