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Author Notes:

Address for reprint requests and other correspondence: A. Wenning, Dept. of Biology, Emory Univ., Atlanta, GA 30322 (e-mail: awennin@emory.edu).

Subjects:

Research Funding:

This work was supported by National Institute of Neurological Disorders and Stroke Grant NS-24072 to R. L. Calabrese.

Keywords:

  • central pattern generator
  • fictive motor pattern
  • heartbeat
  • constriction pattern
  • leech

Bringing up the rear: new premotor interneurons add regional complexity to a segmentally distributed motor pattern

Tools:

Journal Title:

Journal of Neurophysiology

Volume:

Volume 106, Number 5

Publisher:

, Pages 2201-2215

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Central pattern generators (CPGs) pace and pattern many rhythmic activities. We have uncovered a new module in the heartbeat CPG of leeches that creates a regional difference in this segmentally distributed motor pattern. The core CPG consists of seven identified pairs and one unidentified pair of heart interneurons of which 5 pairs are premotor and inhibit 16 pairs of heart motor neurons. The heartbeat CPG produces a side-to-side asymmetric pattern of activity of the premotor heart interneurons corresponding to an asymmetric fictive motor pattern and an asymmetric constriction pattern of the hearts with regular switches between the two sides. The premotor pattern progresses from rear to front on one side and nearly synchronously on the other; the motor pattern shows corresponding intersegmental coordination, but only from segment 15 forward. In the rearmost segments the fictive motor pattern and the constriction pattern progress from front to rear on both sides and converge in phase. Modeling studies suggested that the known inhibitory inputs to the rearmost heart motor neurons were insufficient to account for this activity. We therefore reexamined the constriction pattern of intact leeches. We also identified electrophysiologically two additional pairs of heart interneurons in the rear. These new heart interneurons make inhibitory connections with the rear heart motor neurons, are coordinated with the core heartbeat CPG, and are dye-coupled to their contralateral homologs. Their strong inhibitory connections with the rearmost heart motor neurons and the small side-to-side phase difference of their bursting contribute to the different motor and beating pattern observed in the animal's rear.

Copyright information:

© 2011 the American Physiological Society

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