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Author Notes:

Correspondence to: Hans E. Grossniklaus MD, MBA, L.F. Montgomery Ophthalmic Pathology Laboratory, BT 428 Emory Eye Center, 1365 Clifton Road, Atlanta, GA 30322, Phone: 404-778-4611, Fax: 404-778-4610, Email: ophtheg@emory.edu.

Dr. Hans Grossniklaus had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.


Residual Intraretinal Retinoblastoma After Chemoreduction Failure


Journal Title:

Archives of ophthalmology (Chicago, Ill. : 1929)


Volume 130, Number 2


, Pages 246-248

Type of Work:

Article | Post-print: After Peer Review


Over the past decade, chemoreduction has become the treatment of choice for the initial management of retinoblastoma. Yet despite its established use, chemoreduction has not been able to treat diffuse infiltrating retinoblastoma, the least common subtype of retinoblastoma. Herein we report two cases in which residual intraretinal retinoblastoma exhibiting flat and diffuse infiltration was found on pathological exam after a chemoreduction failure. The chemoreduction reduced some of the tumor and unmasked the intraretinal component.

Copyright information:

© 2012 American Medical Association. All rights reserved.

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