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Author Notes:

Address for reprint requests and other correspondence: S. Hochman, Dept. of Physiology, Emory Univ. School of Medicine, 615 Michael St., Atlanta, GA 30322 (e-mail: shawn.hochman@emory.edu).

Subjects:

Research Funding:

The author is indebted to the following funding agencies: Christopher and Dana Reeve Foundation, Craig Neilsen Foundation, Paralyzed Veterans of America, National Science Foundation #0745164, National Institutes of Health awards EB-006179, NS-045248, NS-40893, and NS-40440.

Keywords:

  • spinal cord
  • perforated patch
  • interneuron

Long-term patch recordings from adult spinal neurons herald new era of opportunity

Tools:

Journal Title:

Journal of Neurophysiology

Volume:

Volume 106, Number 6

Publisher:

, Pages 2794-2795

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Recently, Andreas Husch, Nathan Cramer, and Ronald M. Harris-Warrick achieved a remarkable breakthrough in patch-clamp recordings of ventral horn neurons in the adult spinal cord slice preparation. This landmark study that breaks the “age barrier” is titled “Long-duration perforated patch recordings from spinal interneurons of adult mice” (Husch et al., in press). In it, the authors demonstrate the unprecedented ability to undertake day-long (up to 12 h), and utterly stable perforated patch recordings. A description of the methodology is detailed in their paper. Here, I give a brief overview before providing context to this extraordinary achievement.

Copyright information:

Copyright © 2011 the American Physiological Society

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