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Author Notes:

Author correspondence: Vin Tangpricha (Email: vin.tangpricha@emory.edu)

JDF and VT analyzed data.

JDF, RG, and VT wrote the paper.

VT had primary responsibility for final content.

All authors read and approved the final manuscript.

Author disclosures: J. D. Finklea, R. E. Grossmann, and V. Tangpricha, no conflicts of interest.

Subjects:

Research Funding:

Supported by NIH K23 AR054334 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH T32DK007734 from The National Institute of Diabetes and Digestive and Kidney Diseases, NIH 5UL1RR025008 from the National Center for Research Resources, and by a Cystic Fibrosis Foundation Center Grant to the Emory Cystic Fibrosis Center.

Vitamin D and Chronic Lung Disease: A Review of Molecular Mechanisms and Clinical Studies

Tools:

Journal Title:

Advances in Nutrition

Volume:

Volume 2, Number 3

Publisher:

, Pages 244-253

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Vitamin D is classically recognized for its role in calcium homeostasis and skeletal metabolism. Over the last few decades, vitamin D deficiency has increased in prevalence in adults and children. Potential extraskeletal effects of vitamin D have been under investigation for several diseases. Several cross-sectional studies have associated lower vitamin D status with decreased lung function. This finding has prompted investigators to examine the association of vitamin D deficiency with several chronic lung diseases. One major focus has been the link between maternal vitamin D status and childhood asthma. Vitamin D deficiency has also been associated with increased risk of respiratory infection from influenza A and Mycobacterium tuberculosis. Other chronic respiratory diseases associated with vitamin D deficiency include cystic fibrosis, interstitial lung disease, and chronic obstructive pulmonary disease. This review will examine the current clinical literature and potential mechanisms of vitamin D in various pulmonary diseases.

Copyright information:

© 2011 American Society for Nutrition

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