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Correspondence: loguem@bu.edu
Author contributions: Authors MWL, MWM, EJW, BRH, FGM, AKS, and NPD contributed to study design, data interpretation, and drafting of the manuscript. MWL, ZZ, and YZ analyzed data and/or prepared figures and tables for the manuscript. consortium meta-analysis used for replication.
MU, CMN, AEA-K, DGB, JCB, MEG, MPB, EG, GAG, MAH, RCK, NAK, AXM, CEM, X-JQ, VBR, BPFR, MBS, RJU, EV, CHV, and EBW contributed to the. AS and SAS contributed to the generation of the DNAm data for the TRACTS study. REM, WPM, JPH, and MV supplied samples and phenotype data used in the study. All authors reviewed and approved the manuscript prior to submission.
Disclosures: FM participated in this study while also an NIMH-funded research post-doctoral fellow at Boston University/VA Boston Healthcare System, but is currently an employee of BlackThorn Therapeutics.
MBS has in the past 3 years been a consultant for Actelion, Aptinyx, Bionomics, Dart Neuroscience, Healthcare Management Technologies, Janssen, Neurocrine Biosciences, Oxeia Biopharmaceuticals, Pfizer, and Resilience Therapeutics
In the past 3 years, RCK received support for his epidemiological studies from Sanofi Aventis; was a consultant for DataStat, Inc., Johnson & Johnson Wellness and Prevention, Sage Pharmaceuticals, Shire, Takeda; and served on an advisory board for the Johnson & Johnson Services Inc. Lake Nona Life Project.
None of the remaining authors have any conflicts to disclose. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs, the Department of Defense, NIMH, or the US government.
This work was funded by I01BX003477, a Department of Veterans Affairs BLR&D grant to MWL, 1R03AG051877, 1R21AG061367-01, and 1I01CX001276-01A2 to EJW, 5T32MH019836-18 to FGM, R21MH102834 to MWM, 1R01MH108826 to Smith/Logue/Nievergelt/Uddin, the National Center for PTSD: Behavioral Sciences Division, and the Translational Research Center for TBI and Stress Disorders (TRACTS), a Department of Veterans Affairs Rehabilitation Research and Development (RR&D) Traumatic Brain Injury Center of Excellence (B3001-C) at VA Boston Healthcare System. Genotype and methylation data for the TRACTS and Brain Bank Cohort was generated with the support of resources and of facilities at the Pharmacogenomics Analysis Laboratory (Research Service, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas),
a core research laboratory funded by the Cooperative Studies Program, Research and Development, Department of Veterans Affairs. Marine Resiliency Study (MRS) funding from The Marine Corps, Navy Bureau of Medicine and Surgery (BUMED) and VA Health Research and Development (HSR&D) who provided funding for MRS data collection and analysis (PI DGB) and NIH R01MH093500 which funded the GWAS assays and analysis (PI CMN). Army STARRS was sponsored by the Department of the Army and funded under cooperative agreement number U01MH087981 (2009-2015) with the National Institutes of Health, National Institute of Mental Health (NIH/NIMH). Subsequently, STARRS-LS was sponsored and funded by the Department of Defense (USUHS grant no. HU0001-15-2-0004).
Data collection of PRISMO was funded by the Dutch Ministry of Defence, and DNA methylation analyses in PRISMO were funded by the VENI Award fellowship from the Netherlands Organisation for Scientific Research (NWO, grant no. 916.11.086).
The PTSD and TBI Injury and Traumatic Stress Clinical Consortium (INTRuST) was funded by a grant from the US Department of Defense (PI: Stein, MB): W81XWH08-2-0159. Mid-Atlantic Mental Illness Research Education and Clinical Center the study of Post-Deployment Mental Health Study funding included a Clinical Sciences Research and Development (CSR&D) Research Career Scientist Award (#11S-RCS-009) to Dr. Beckham, a CSR&D Career Development Award (#IK2 CX000525) to Dr. Kimbrel, and Biomedical and Laboratory Research and Development (BLR&D) Merit Award to Dr. Beckham from the US Department of Veterans Affairs (VA).
This work was also supported by the VA Mid-Atlantic Mental Illness Research, Education and Clinical Center (MIRECC), the Durham Veterans Affairs Medical Center, the VA Office of Mental Health Services, and the VA Office of Research and Development.
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