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Author Notes:

Kathleen Withers, Cedar, Cardiff and Vale University Health Board, Cardiff Medicentre, Heath Park, Cardiff, CF14 4UJ, UK. kathleen.withers@wales.nhs.uk

The authors thank Peter O'Callaghan (Cardiology Dept., Cardiff and Vale UHB) and Stephen Murray (Cardiology Dept., Newcastle Upon Tyne Hospitals NHS Foundation Trust), for clinical support, and David Cunningham (National Institute for Cardiovascular Outcomes Research, UCL, London) for database support, Racheal James (Cardiology Dept., Cardiff and Vale UHB) for patient enrolment, and Ann James (Cedar, Cardiff and Vale UHB) for administrative support and data entry.

We would also like to thank all the patients involved in this study.

In honorable memory of Dr. David Cunningham.


Research Funding:

The research was facilitated by Cedar, Cardiff & Vale UHB, on behalf of NICE (The National Centre for Health and Care Excellence) as part of their contract as an External Assessment Centre.

The clinical work was funded by the NHS under normal arrangements for clinical governance and consent.

This work was supported by the National Institute for Health and Care Excellence (NICE). Cedar, Cardiff and Vale University Health Board (institution of JE, KW, GCR) is funded by NICE.

The clinical work was not funded by NICE but was carried out under normal arrangements.

Funding to pay for open access of this article was provided by Cedar.


  • Science & Technology
  • Life Sciences & Biomedicine
  • Technology
  • Cardiac & Cardiovascular Systems
  • Engineering, Biomedical
  • Cardiovascular System & Cardiology
  • Engineering
  • atrial fibrillation
  • cardiac ablation
  • cardiac arrhythmia
  • quality of life
  • symptoms

Quality of life benefits from arrhythmia ablation: A longitudinal study using the C-CAP questionnaire and EQ5D


Journal Title:



Volume 42, Number 6


, Pages 705-711

Type of Work:

Article | Final Publisher PDF


Aims: To investigate long-term efficacy of cardiac ablation for symptomatic arrhythmia by gathering generic and arrhythmia-related quality of life data using patient-reported outcome measures before and after ablation. Methods: Consecutive patients undergoing cardiac ablation procedures at three sites in the United Kingdom were enrolled (n = 561). Data were collected at baseline, at 8–16 weeks, and 12 months after the ablation with responses from 390 patients received at all three time points. Nonparametric tests were used to identify any changes in patient outcomes due to nonnormal data. Results: There were significant improvements in symptom severity, impact on life scores, EQ-5D-5L indices, and visual analogue score (VAS) scores at pre- versus 3 months and at preablation versus 1 year. Impact on life score showed additional improvement at 1 year versus 3 months, while improvements in symptom severity, EQ-5D-5L indices, and VAS scores continued to be maintained between 3 months and 1 year. Conclusion: Cardiac ablation provides patients with arrhythmias relief from symptoms, and results in an improvement in quality of life. Improvements observed at 3 months are maintained at 1 year follow-up.

Copyright information:

© 2019 The Authors. Pacing and Clinical Electrophysiology published by Wiley Periodicals, Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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