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Author Notes:

Jack L Arbiser, Department of Dermatology, Emory University School of Medicine, WMB 5309, 1639 Pierce Drive, Atlanta, GA 30322, Tel (404) 727-5063, Fax (404) 727-5897, jarbise@emory.edu.

Dr. Maley and Arbiser performed the research, analyzed the data and wrote the paper.

Drs. Maley and Arbiser have no conflicts of interest to report.

Subject:

Research Funding:

Dr. Arbiser was supported by the grant RO1 AR47901and P30 AR42687 Emory Skin Disease Research Core Center Grant from the National Institutes of Health; a Veterans Administration Hospital Merit Award; as well as funds from the Margolis Foundation; Rabinowitch-Davis Foundation for Melanoma Research; and the Betty Minsk Foundation for Melanoma Research.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Dermatology
  • crystal violet
  • Gentian Violet
  • triphenylmethane dye
  • CRYSTAL VIOLET
  • HEMORRHAGIC CYSTITIS
  • URINARY CATHETERS
  • GENETIC TOXICITY
  • CANDIDA SPP.
  • INFECTION
  • THERAPY
  • CANCER
  • DYES
  • CARCINOGENICITY

Gentian Violet: a 19th century drug re-emerges in the 21st century

Tools:

Journal Title:

Experimental Dermatology

Volume:

Volume 22, Number 12

Publisher:

, Pages 775-780

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Gentian violet (GV) has a long and varied history as a medicinal agent. Historically used as an antibacterial and antifungal, recent reports have shown its utility as an antitypranosomal, antiviral and anti-angiogenic agent. The objective of this article is to summarize evidence regarding the efficacy and safety of GV use in dermatology. Recent discoveries have found novel targets of GV, namely NADPH oxidase in mammalian cells and thioredoxin reductase 2 in bacterial, fungal and parasitic cells. These discoveries have expanded the use of GV in the 21st century. Given that GV is well tolerated, effective and inexpensive, its use in dermatology is predicted to increase.

Copyright information:

© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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