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Author Notes:

Correspondence to: Jocelyne Bachevalier, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329. Phone: 404-727-9765, Fax: 404-727-8088, jbachev@emory.edu

We thank the veterinary and animal husbandry staff at the Yerkes National Primate Research Center for expert animal care, the imaging core facility for the care and handling of animals during the MR imaging procedures, and Browyn Briseno, Rebecca Grizzard, Amy Mahan, and Anthony Gazy for assistance with the testing of the animals and scoring the videotapes.

We also thank Maria Alvarado for helpful comments on an earlier version of this manuscript.

None of the contributing authors have any conflicts of interest in the conduct or reporting of this research.

Subjects:

Research Funding:

This work was supported by the National Institute of Mental Health (MH-58846), and the National Center for Research Resources P51RR165, currently supported by the Office of Research Infrastructure Programs/OD P51OD11132.

Keywords:

  • Functional plasticity
  • Incidental recognition
  • Macaca mulatta
  • Medial temporal lobe
  • Novelty preference
  • Visual-paired-comparison
  • Aging
  • Animals
  • Animals, Newborn
  • Cerebral Cortex
  • Exploratory Behavior
  • Female
  • Hippocampus
  • Macaca mulatta
  • Neuroimmunomodulation
  • Pattern Recognition, Visual
  • Recognition (Psychology)
  • Social Behavior
  • Temporal Lobe
  • Visual Perception

The development of object recognition memory in rhesus macaques with neonatal lesions of the perirhinal cortex

Tools:

Journal Title:

Developmental Cognitive Neuroscience

Volume:

Volume 11

Publisher:

, Pages 31-41

Type of Work:

Article | Final Publisher PDF

Abstract:

To investigate the role of the perirhinal cortex on the development of recognition measured by the visual paired-comparison (VPC) task, infant monkeys with neonatal perirhinal lesions and sham-operated controls were tested at 1.5, 6, 18, and 48 months of age on the VPC task with color stimuli and intermixed delays of 10 s, 30 s, 60 s, and 120 s. Monkeys with neonatal perirhinal lesions showed an increase in novelty preference between 1.5 and 6 months of age similar to controls, although at these two ages, performance remained significantly poorer than that of control animals. With age, performance in animals with neonatal perirhinal lesions deteriorated as compared to that of controls. In contrast to the lack of novelty preference in monkeys with perirhinal lesions acquired in adulthood, novelty preference in the neonatally operated animals remained above chance at all delays and all ages. The data suggest that, although incidental recognition memory processes can be supported by the perirhinal cortex in early infancy, other temporal cortical areas may support these processes in the absence of a functional perirhinal cortex early in development. The neural substrates mediating incidental recognition memory processes appear to be more widespread in early infancy than in adulthood.

Copyright information:

© 2014 The Authors.Published by Elsevier Ltd.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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