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Author Notes:

David A. Nicholson, Department of Biology, Emory University, Atlanta, 30322, Georgia. Email: dnicho4@emory.edu

We are grateful to the laboratories of Donna Maney and Dieter Jaeger at Emory University for material support.

The authors declare no conflicts of interest.

Subjects:

Research Funding:

This work was supported by NIH grants R01NS084844 (SJS) and R01DC014364 (TFR) and NSF grants IOS-1456912 (SJS), IOS-1457206 (TFR), and IOS-1451034 (TFR).

Imaging acquisition was supported by the Emory University Integrated Cellular Imaging Microscopy Core of the Emory Neuroscience NINDS Core Facilities grant, 5P30NS055077.

Keywords:

  • thalamostriatal
  • songbird
  • basal ganglia
  • cerebellum
  • RRID: AB_2209751
  • RRID: AB_2536611
  • RRID: AB_2534132
  • RRID: AB_2534134
  • RRID: AB_2174013
  • RRID: AB_2340613
  • RRID: AB_2340675
  • RRID: AB_2340846
  • RRID: AB_2313584
  • RRID: AB_2313581

Thalamostriatal and cerebellothalamic pathways in a songbird, the Bengalese finch

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Journal Title:

Journal of Comparative Neurology

Volume:

Volume 526, Number 9

Publisher:

, Pages 1550-1570

Type of Work:

Article | Post-print: After Peer Review

Abstract:

The thalamostriatal system is a major network in the mammalian brain, originating principally from the intralaminar nuclei of thalamus. Its functions remain unclear, but a subset of these projections provides a pathway through which the cerebellum communicates with the basal ganglia. Both the cerebellum and basal ganglia play crucial roles in motor control. Although songbirds have yielded key insights into the neural basis of vocal learning, it is unknown whether a thalamostriatal system exists in the songbird brain. Thalamic nucleus DLM is an important part of the song system, the network of nuclei required for learning and producing song. DLM receives output from song system basal ganglia nucleus Area X and sits within dorsal thalamus, the proposed avian homolog of the mammalian intralaminar nuclei that also receives projections from the cerebellar nuclei. Using a viral vector that specifically labels presynaptic axon segments, we show in Bengalese finches that dorsal thalamus projects to Area X, the basal ganglia nucleus of the song system, and to surrounding medial striatum. To identify the sources of thalamic input to Area X, we map DLM and cerebellar-recipient dorsal thalamus (DTCbN). Surprisingly, we find both DLM and dorsal anterior DTCbN adjacent to DLM project to Area X. In contrast, the ventral medial subregion of DTCbN projects to medial striatum outside Area X. Our results suggest the basal ganglia in the song system, like the mammalian basal ganglia, integrate feedback from the thalamic region to which they project as well as thalamic regions that receive cerebellar output.

Copyright information:

VC 2018 Wiley Periodicals, Inc.

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