About this item:

101 Views | 75 Downloads

Author Notes:

Correspondence: Tanya N. Turan, Associate Professor of Neurology, Director, MUSC Stroke Division, Department of Neurology, 19 Hagood Ave., Harborview Office Tower, Suite 501, Charleston, SC 29425-8050, phone: 843-792-3020, fax: 843-792-2484, turan@musc.edu.

JYC, KVDM, MJG, TL, TRB, SA, TJC, ARC, RHS, EF and TNT: designed the phantom and imaging experiments, performed the experiments, analyzed and processed the data, drafted the manuscript.

RMK and OWB: contributed to phantom modeling and MR characterization, revised the draft manuscript.

TL, TRB, SA, TJC, AKB, XJZ, HM, SZ, JWR, and RHS: acquired imaging data, revised the manuscript.

MJG: Has been a consultant on a fee-per-hour basis for Codman Neurovascular, InNeuroCo Inc, and Stryker Neurovascular; holds stock in InNeuroCo; and research support from the National Institutes of Health (NIH), Cerevasc LLC, Codman Neurovascular, the Cure Tay Sachs Foundation, and Gentuity LLC, InNeuroCo, Medtronic Neurovascular, Microvention/Terumo, Mivi Neuroscience, Neuravi, Neurogami, Neuronal Protection Systems, Rapid Medical, R92M LLC, Philips Healthcare, Stryker Neurovascular, the Wyss Institute.

SA: NIH 1R21HL130969

RHS: The Heart and Stroke Foundation of Canada New Investigator Award, the Canadian Partnership for Stroke Recovery and the Department of Medicine at Sunnybrook and University of Toronto.

TNT: NINDS 5R21-TW010356-02


Research Funding:

This work was supported in part by NINDS 5R21-TW010356-02 (to TNT).


  • Science & Technology
  • Life Sciences & Biomedicine
  • Neuroimaging
  • Surgery
  • Neurosciences & Neurology
  • Atherosclerosis
  • MRI
  • Stenosis
  • Vessel Wall

Development of a high resolution MRI intracranial atherosclerosis imaging phantom

Show all authors Show less authors


Journal Title:

Journal of NeuroInterventional Surgery


Volume 10, Number 2


, Pages 143-+

Type of Work:

Article | Post-print: After Peer Review


Background and purpose Currently, there is neither a standard protocol for vessel wall MR imaging of intracranial atherosclerotic disease (ICAD) nor a gold standard phantom to compare MR sequences. In this study, a plaque phantom is developed and characterized that provides a platform for establishing a uniform imaging approach for ICAD. Materials and methods A patient specific injection mold was 3D printed to construct a geometrically accurate ICAD phantom. Polyvinyl alcohol hydrogel was infused into the core shell mold to form the stenotic artery. The ICAD phantom incorporated materials mimicking a stenotic vessel and plaque components, including fibrous cap and lipid core. Two phantoms were scanned using high resolution cone beam CT and compared with four different 3 T MRI systems across eight different sites over a period of 18 €months. Inter-phantom variability was assessed by lumen dimensions and contrast to noise ratio (CNR). Results Quantitative evaluation of the minimum lumen radius in the stenosis showed that the radius was on average 0.80 €mm (95% CI 0.77 to 0.82 mm) in model 1 and 0.77 €mm (95% CI 0.74 to 0.81 mm) in model 2. The highest CNRs were observed for comparisons between lipid and vessel wall. To evaluate manufacturing reproducibility, the CNR variability between the two models had an average absolute difference of 4.31 (95% CI 3.82 to 5.78). Variation in CNR between the images from the same scanner separated by 7 €months was 2.5-6.2, showing reproducible phantom durability. Conclusions A plaque phantom composed of a stenotic vessel wall and plaque components was successfully constructed for multicenter high resolution MRI standardization.

Copyright information:

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved.

Export to EndNote