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Author Notes:

Corresponding authors: Email: Daniel A Wagenaar* - dwagenaar@ucsd.edu; Steve M Potter* - steve.potter@bme.gatech.edu

DAW collected all data, performed the analysis, and prepared text and figures for the manuscript.

JP and SMP contributed to the design of the study and to the preparation of the manuscript.

We thank our lab technician, Sheri McKinney.

The author(s) declare that they have no competing interests.


Research Funding:

This work was partially supported by NINDS grants NS38628 (to SMP) and NS44134 (to JP), by NIBIB grant EB00786 (to SMP), by the Whitaker Foundation, and the Center for Behavioral Neuroscienc


  • Animals
  • Cells, Cultured
  • Cerebral Cortex
  • Electric Stimulation
  • Electrodes
  • Electrophysiology
  • Microarray Analysis
  • Neuronal Plasticity
  • Neurons
  • Rats

Searching for plasticity in dissociated cortical cultures on multi-electrode arrays


Journal Title:

Journal of Negative Results in BioMedicine


Volume 5, Number 1


, Pages 16-16

Type of Work:

Article | Final Publisher PDF


We attempted to induce functional plasticity in dense cultures of cortical cells using stimulation through extracellular electrodes embedded in the culture dish substrate (multi-electrode arrays, or MEAs). We looked for plasticity expressed in changes in spontaneous burst patterns, and in array-wide response patterns to electrical stimuli, following several induction protocols related to those used in the literature, as well as some novel ones. Experiments were performed with spontaneous culture-wide bursting suppressed by either distributed electrical stimulation or by elevated extracellular magnesium concentrations as well as with spontaneous bursting untreated. Changes concomitant with induction were no larger in magnitude than changes that occurred spontaneously, except in one novel protocol in which spontaneous bursts were quieted using distributed electrical stimulation.

Copyright information:

© 2006 Wagenaar et al; licensee BioMed Central Ltd.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 2.0 Generic License (http://creativecommons.org/licenses/by/2.0/).

Creative Commons License

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