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Author Notes:

Correspondence: gretchen.neigh@emory.edu.

CLN participated in study design, immunohistochemical procedures, analysis and interpretation of data, and drafting of the manuscript.

RR carried out immunohistochemical procedures and quantification.

MB participated in immunohistochemical quantification and image collection.

JB maintained animals and performed behavioral testing.

GNN is responsible for project conception and design, data interpretation, and was involved in critical revision of the manuscript.

We would like to thank Darrell Eacret for his assistance with this project.

The authors declare that they have no competing interests.


Research Funding:

American Heart Association, National Alliance for Research in Schizophrenia and Affective Disorders


  • Science & Technology
  • Life Sciences & Biomedicine
  • Immunology
  • Neurosciences
  • Neurosciences & Neurology
  • Sex differences
  • Vascular ischemia
  • Animal model
  • Behavior
  • Microglia

Microglial activation occurs in the absence of anxiety-like behavior following microembolic stroke in female, but not male, rats


Journal Title:

Journal of Neuroinflammation


Volume 11, Number 1


, Pages 174-174

Type of Work:

Article | Final Publisher PDF


Background: The incidence of depression and anxiety disorders is twice as high in women than men; however, females exhibit less neuronal damage following an equivalent ischemic event. Microembolic stroke increases anxiety- and depressive-like behaviors in male rats but the behavioral repercussions in females are unknown. Findings: Given the relative neuronal protection from stroke in ovary-intact females, female rats exposed to microembolic stroke may be behaviorally protected as compared to males. The data presented demonstrate that anxiety-like behavior is increased in males despite a comparable increase in microglial activation following microembolic stroke in both males and females. Conclusions: These data suggest that males may be more behaviorally susceptible to the effects of microembolic stroke and further illustrate a dissociation between neuroinflammation and behavior in females.

Copyright information:

© 2014 Nemeth et al.; licensee BioMed Central Ltd. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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