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Author Notes:

Qian Yang: Email: Email: qianyang@fmmu.edu.cn

The authors declare that there is no conflict of interests regarding the publication of this paper.

Subjects:

Research Funding:

This work was partially supported by FMMU Research Foundation (Qian Yang), Chinese National 973 Project (Grant no. 2011CB510000) (Qian Yang), and National Natural Science Foundation of China (Grant no. 31371400) (Qian Yang).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Clinical Neurology
  • Neurosciences & Neurology
  • MYOCYTE ENHANCER FACTOR-2
  • CYCLIN-DEPENDENT KINASE-5
  • TRANSCRIPTION FACTOR MEF2
  • SURVIVAL FACTOR MEF2D
  • COMPLEX I DEFICIENCY
  • OXIDATIVE STRESS
  • ALPHA-SYNUCLEIN
  • NEURODEGENERATIVE DISEASES
  • CELL-SURVIVAL
  • PINK1/PARKIN-MEDIATED MITOPHAGY

Chaperone-Mediated Autophagy and Mitochondrial Homeostasis in Parkinson's Disease

Tools:

Journal Title:

Parkinson's Disease

Volume:

Volume 2016

Publisher:

, Pages 2613401-2613401

Type of Work:

Article | Final Publisher PDF

Abstract:

Parkinson's disease (PD), a complex neurodegenerative disorder, is pathologically characterized by the formation of Lewy bodies and loss of dopaminergic neurons in the substantia nigra pars compacta (SNc). Mitochondrial dysfunction is considered to be one of the most important causative mechanisms. In addition, dysfunction of chaperone-mediated autophagy (CMA), one of the lysosomal proteolytic pathways, has been shown to play an important role in the pathogenesis of PD. An exciting and important development is recent finding that CMA and mitochondrial quality control may be linked. This review summarizes the studies revealing the link between autophagy and mitochondrial function. Discussions are focused on the connections between CMA and mitochondrial failure and on the role of MEF2D, a neuronal survival factor, in mediating the regulation of mitochondria in the context of CMA. These new findings highlight the need to further explore the possibility of targeting the MEF2D-mitochondria-CMA network in both understanding the PD pathogenesis and developing novel therapeutic strategies.

Copyright information:

© 2016 Ruixin Yang et al.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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