Stefan Sarafianos

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Works 1-10 of 45

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Article

Conformational Changes in HIV-1 Reverse Transcriptase that Facilitate Its Maturation

by Ryan L. Slack; Tatiana V. Ilina; Zhaoyong Xi; Nicholas S. Giacobbi; Gota Kawai; Michael A. Parniak; Stefan Sarafianos; Nicolas Sluis Cremer; Rieko Ishima

2019

Article

Structural Implications of Genotypic Variations in HIV-1 Integrase From Diverse Subtypes

by Leonard Rogers; Adetayo E. Obasa; Graeme B. Jacobs; Stefan Sarafianos; Anders Sonnerborg; Ujjwal Neogi; Kamalendra Singh

2018

Article

Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules

by Sanjeev Kumar V. Vernekar; Rajkumar Lalji Sahani; Mary C. Casey; Jayakanth Kankanala; Lei Wang; Karen Kirby; Haijuan Du; Huanchun Zhang; Philip Tedbury; Jiashu Xie; Stefan Sarafianos; Zhengqiang Wang

2020

Article

Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket

by Pierrick Craveur; Anna T. Gres; Karen Kirby; Dandan Liu; John A. Hammond; Yisong Deng; Stefano Forli; David S. Goodsell; James R. Williamson; Stefan Sarafianos; Arthur J. Olson

2019

Article

Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus

by Dandan Liu; Philip Tedbury; Shuiyun Lan; Andrew D. Huber; Maritza N. Puray-Chavez; Juan Ji; Eleftherios Michailidis; Mohsan Saeed; Tanyaradzwa P. Ndongwe; Leda Bassit; Raymond Schinazi; Robert Ralston; Charles M. Rice; Stefan Sarafianos

2019

Article

Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus

by Alicia Martinez-Lopez; Mirjana Persaud; Maritza Puray Chavez; Hongjie Zhang; Lijun Rong; Shufeng Liu; Tony T. Wang; Stefan Sarafianos; Felipe Diaz-Griffero

2019

Article

6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H

by Lei Wang; Jing Tang; Andrew Huber; Mary Casey; Karen Kirby; Daniel J Wilson; Jayakanth Kankanala; Michael A. Parniak; Stefan Sarafianos; Zhengqiang Wang

2018

Article

6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity

by Lei Wang; Jing Tang; Andrew Huber; Mary Casey; Karen Kirby; Daniel J. Wilson; Jayakanth Kankanala; Jiashu Xie; Michael A. Parniak; Stefan Sarafianos; Zhengqiang Wang

2018

Article

The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase

by Yuki Takamatsu; Debananda Das; Satoru Kohgo; Hironori Hayashi; Nicole S. Delino; Stefan Sarafianos; Hiroaki Mitsuya; Kenji Maeda

2018