Rabindra Tirouvanziam PhD, Engineer


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External Links (e.g. Departmental web site):

Degrees Held:

  • PhD, Agro Paris-Tech, 1999
  • Engineer, Agro Paris-Tech, 1994

Biography/Description of Research:

Previously at the Institute of Embryology at the College de France, in Paris, and at Stanford University, Dr. Tirouvanziam has led efforts to revisit the biology of granulocytic subsets in human, mouse, SCID-Hu xenografts and Drosophila. In particular, his work has demonstrated that in CF patients, airway neutrophils are alive and reprogrammed, rather than necrotic, while carrying out severe damage to the patients' airways. This new paradigm holds much promise for the development of neutrophil-targeted therapies for CF. In keeping with this goal, a key interest in our group is to study how neutrophils are reprogrammed by the evolving CF airway ecosystem, from birth all the way to end-stage disease. This will aid in mapping and modeling the longitudinal trajectory and junctures (or inflexion points) in airway ecosystem evolution and immune adaptation in CF patients, to advance towards personalized medicine. Here are the main questions that we are investigating in our CF patient-based studies: - Nutrients, transporters and intracellular pathways involved in the reprogramming of airway neutrophils - Effector and autocrine/paracrine regulatory functions carried out by subsets of airway neutrophils - Mechanisms of ecosystem building involving host epithelium, neutrophils and pathogens Although CF is our main area of focus, our group maintains active projects in other diseases and conditions affecting the respiratory system (chronic obstructive pulmonary disease, lung transplant), immune system (allergy, fungal colonization, malaria, Fanconi anemia, rheumatoid arthritis) and central nervous system (autism, schizophrenia). We have fruitful collaborations with groups at several academic institutions, including Emory University, Georgia Tech, Stanford University, University of Alabama at Birmingham, University of Montpellier (France) and University of Lausanne (Switzerland). Our approach emphasizes sample collection from patients and direct, high-content analyses by flow I image cytometry (to characterize metabolic and activation markers reflecting adaptation in immune cells) and mass spectrometry (to characterize small molecule signals exchanged by mucosal cells, viruses I bacteria I fungi and immune cells). In addition, we have developed a novel transmigration model enabling physiological studies of human airway epithelium I leukocyte I pathogen cocultures, using isolates from patients and candidate drugs, which we analyze by the above methods, and confocal imaging. From an engineering standpoint, we are interested in identifying better in vivo targets and in developing adequate measurement methods to enable better immuno-inflammatory monitoring at the clinic and at home.

Works 1-10 of 39

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Cysteine/glutathione deficiency: A significant and treatable corollary of disease

by Pietro Ghezzi; Kevin V. Lemley; James P. Andrus; Stephen C. De Rosa; Ame Holmgren; Dean Jones; Farook Jahoor; Richard Kopke; Ian Cotgreave; Teodoro Bottiglieri; Neil Kaplowitz; Hajime Nakamura; Frank Staal; Stephen W. Ela; Kondala R. Atkuri; Rabindra Tirouvanziam; Kartoosh Heydari; Bita Sahaf; Andrew Zolopa; Richard Eugene Frye; John J. Mantovani; Leonard A. Herzenberg; Leonare A. Herzenberg



MaHPIC malaria systems biology data from Plasmodium cynomolgi sporozoite longitudinal infections in macaques

by Jeremy D DeBarry; Mustafa V Nural; Suman B Pakala; Vishal Nayak; Susanne Warrenfeltz; Jay Humphrey; Stacey A Lapp; Monica Cabrera-Mora; Cristiana FA Brito; Jianlin Jiang; Celia L Saney; Allison Hankus; Hannah M Stealey; Megan B DeBarry; Nicolas Lackman; Noah Legall; Kevin Lee; Yan Tang; Anuj Gupta; Elizabeth D Trippe; Robert R Bridger; Daniel Brent Weatherly; Mariko S Peterson; Xuntian Jiang; ViLinh Tran; Karan Uppal; Luis L Fonseca; Chester J Joyner; Ebru Karpuzoglu; Regina J Cordy; Esmeralda Meyer; Lance L Wells; Daniel S Ory; Frances Lee; Rabindra Tirouvanziam; Juan B Gutiérrez; Chris Ibegbu; Tracey J Lamb; Jan Pohl; Sarah T Pruett; Dean Jones; Mark P Styczynski; Eberhard Voit; Alberto Moreno; Mary Galinski; Jessica C Kissinger



Pseudomonas aeruginosa modulates neutrophil granule exocytosis in an in vitro model of airway infection

by Daniel R Laucirica; Craig J Schofield; Samantha A McLean; Camilla Margaroli; Patricia Agudelo-Romero; Stephen M Stick; Rabindra Tirouvanziam; Anthony Kicic; Luke W Garratt



Airway macrophages display decreased expression of receptors mediating and regulating scavenging in early cystic fibrosis lung disease

by Rabindra Tirouvanziam; Limin Peng; LJM Slimmen; VDD Giacalone; C Schofield; H Horati; BHAN Manai; SCC Estevao; LWW Garratt; HMM Janssens; WWJ Unger



Airway profile of bioactive lipids predicts early progression of lung disease in cystic fibrosis

by Hamed Horati; Hettie M Janssens; Camilla Margaroli; Mieke Veltman; Marta Stolarczyk; Matthew B Kilgore; Jeffrey Chou; Limin Peng; Harm AMW Tiddens; Joshua Chandler; Rabindra Tirouvanziam; Bob J Scholte



Low Doses of Imatinib Induce Myelopoiesis and Enhance Host Anti-microbial Immunity

by Ruth J. Napier; Brian A Norris; Alyson Swimm; Cynthia R Giver; Wayne A. C. Harris; Julie Laval; Brooke A. Napier; Gopi Patel; Ryan Crump; Zhenghong Peng; William Bornmann; Bali Pulendran; Mark Buller; David S Weiss; Rabindra Tirouvanziam; Edmund K Waller; Daniel Kalman



Transcriptional reprogramming of infiltrating neutrophils drives lung pathology in severe COVID-19 despite low viral load

by Devon J. Eddins; Junkai Yang; Astrid Kosters; Vincent D. Giacalone; Ximo Pechuan-Jorge; Joshua Chandler; Jinyoung Eum; Benjamin R. Babcock; Brian S. Dobosh; Mindy R. Hernandez; Fathma Abdulkhader; Genoah L. Collins; Darya Y. Orlova; Richard Ramonell; Ignacio Sanz; Christine Moussion; F. Eun-Hyung Lee; Rabindra Tirouvanziam; Eliver Ghosn



Transcriptional firing represses bactericidal activity in cystic fibrosis airway neutrophils

by Camilla Margaroli; Diego Moncada-Giraldo; Dalia A Gulick; Brian Dobosh; Vincent D Giacalone; Osric A Forrest; Fangxu Sun; Chunhui Gu; Amit Gaggar; Haydn Kissick; Ronghu Wu; Greg Gibson; Rabindra Tirouvanziam