Michael Natchus

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Works 1-10 of 24

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Article

Small-Molecule Antiviral beta-D-N-4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

by Maria L. Agostini; Andrea J. Pruijssers; James D. Chappell; Jennifer Gribble; Xiaotao Lu; Erica L. Andres; Gregory Bluemling; Mark A. Lockwood; Timothy P. Sheahan; Amy C. Sims; Michael Natchus; Manohar Saindane; Alexander Kolykhalov; George Painter; Ralph S. Baric; Mark R. Denison

2019

Article

4 '-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication

by Julien Sourimant; Carolin M Lieber; Megha Aggarwal; Robert M Cox; Josef D Wolf; Jeong-Joong Yoon; Mart Toots; Chengin Ye; Zachary Sticher; Alexander Kolykhalov; Luis Martinez-Sobrido; Gregory Bluemling; Michael Natchus; George Painter; Richard Plemper

2022

Article

Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

by George Painter; Michael Natchus; Richard Plemper; Alexander Kolykhalov; RM Cox; CM Lieber; JD Wolf; A Karimi; NAP Lieberman; ZM Sticher; P Roychoudhury; MK Andrews; RE Krueger; AL Greninger

2023

Article

4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

by Manohar Saindane; George Painter; Michael Natchus; Richard Plemper; Alexander Kolykhalov; C Lieber; M Aggarwal; J-JK Yoon; RA Cox; H-JM Kang; JA Sourimant; MT Toots; SM Johnson; C Jones; ZR Sticher; SK Tompkins; O Planz; K Sakamoto

2023

Article

SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

by Carolin M Lieber; Robert M Cox; Julien Sourimant; Josef D Wolf; Kate Juergens; Quynh Phung; Manohar Saindane; Meghan K Smith; Zachary M Sticher; Alexander A Kalykhalov; Michael Natchus; George Painter; Kaori Sakamoto; Alexander L Greninger; Richard Plemper

2022

Article

Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding

by Kevin Wittwer; Danielle E Anderson; Kristin Pfeffermann; Robert M Cox; Josef D Wolf; Sabine Santibanez; Annette Mankertz; Roland Plesker; Zachary M Sticher; Alexander A Kolkykhalov; Michael Natchus; Christian K Pfaller; Richard Plemper; Veronika von Messling

2021

Article

Orally efficacious lead of the AVG inhibitor series targeting a dynamic interface in the respiratory syncytial virus polymerase

by Julien Sourimant; Carolin M Lieber; Jeong-Joong Yoon; Mart Toots; Mugunthan Govindarajan; Venkata Udumula; Kaori Sakamoto; Michael Natchus; Joseph Patti; John Vernachio; Richard Plemper

2022

Article

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

by Angela Wahl; Lisa E Gralinski; Claire E Johnson; Wwenbo Yao; Martina Kovarova; Kenneth H Dinnon; Hongwei Liu; Victoria J Madden; Halina M Krzystek; Chandrav De; Krsten K White; Kendra Gully; Alexandra Schäfer; Tanzila Zaman; Sarah R Leist; Paul O Grant; Gregory Bluemling; Alexander Kolykhalov; Michael Natchus; Frederic B Askin; George Painter; Edward P Browne; Corbin D Jones; Raymond J Pickles; Ralph S Baric; Victor Garcia

2021