Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection

• Type of Material: Article
• Authors: Amy C Sherman, Brigham and Women’s Hospital; Xiaoyan Lu, Centers for Disease Control and Prevention, Atlanta; Eileen Schneider, Centers for Disease Control and Prevention, Atlanta; Amelia Langston, Emory University; Carla L Ellis, Northwestern University; Stephen Pastan, Emory University; Julu Bhatnagar, Centers for Disease Control and Prevention, Atlanta; Sarah Reagan-Steiner, Centers for Disease Control and Prevention, Atlanta; Pallavi Annambhotla, Centers for Disease Control and Prevention, Atlanta; Stephen Lindstrom, Centers for Disease Control and Prevention, Atlanta; Aneesh Mehta, Emory University; Stephanie Pouch, Emory University; Marybeth Sexton, Emory University
• Language: English
• Date: 2021-02-25
• Publisher: OXFORD UNIV PRESS INC
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1093/ofid/ofab092
• Title of Journal or Parent Work: OPEN FORUM INFECTIOUS DISEASES
• Volume: 8
• Issue: 3
• Start Page: ofab092
• End Page: ofab092
• Grant/Funding Information: This work was supported by National Institutes of Health (NIH) Vaccinology Training grant (T32AI074492 to A.C.S.).
• Keywords: Infectious Diseases; Immunology; brincidofovir; Science & Technology; adenovirus; renal transplantation; Microbiology; Life Sciences & Biomedicine
• Research Categories: Health Sciences, Pathology; Health Sciences, Medicine and Surgery

Abstract

Background: Human adenovirus (HAdV) infections can lead to high mortality in solid organ transplant (SOT) recipients, with rare reports of donor-derived infection. Methods: Two renal transplant recipients with HAdV-11 infection who received kidneys from the same donor are described. Whole-genome sequencing (WGS) was performed. Results: WGS showed 100% nucleotide sequence identity for the 2 HAdV-11 isolates. The patients presented with distinct clinical syndromes, and both were treated with brincidofovir. Conclusions: Donor-derived HAdV infection is presumed to be low; however, disseminated HAdV in SOT recipients can be severe, and clinicians should be aware of the clinical course and treatment options.