Cell based therapies for ischemic stroke: From basic science to bedside

• Type of Material: Article
• Authors: Xinfeng Liu, Nanjing University; Ruidong Ye, Nanjing University; Tao Yan, Henry Ford Hospital; Shan Ping Yu, Emory University; Ling Wei, Emory University; Gelin Xu, Nanjing University; Xinying Fan, Nanjing University; Yongjun Jiang, Nanjing University; R. Anne Stetler, University of Pittsburgh; George Liu, Peking University; Jieli Chen, Henry Ford Hospital
• Language: English
• Date: 2014-04-01
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: Copyright © 2013 Elsevier Ltd. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.pneurobio.2013.11.007
• Title of Journal or Parent Work: Progress in Neurobiology
• ISSN: 0301-0082
• Volume: 115
• Start Page: 92
• End Page: 115
• Grant/Funding Information: This work was supported by National Natural Science Foundation of China 31300900 (RY); 81300993 (TY); Jiangsu Provincial Special Program of Medical Science (BL2013025); National Institute on Aging of USA AG031811 (JC); and National Institute of Health of USA NS057255 (SPY); NS058710 (WL); and R41NS080329 (JC).
• Keywords: Life Sciences & Biomedicine; FOCAL CEREBRAL-ISCHEMIA; Cell-based therapies; ARTERY OCCLUSION MODEL; Stem cells; MARROW STROMAL CELLS; Neurosciences; ACUTE MYOCARDIAL-INFARCTION; MESENCHYMAL STEM-CELLS; UMBILICAL-CORD BLOOD; Ischemic stroke; Neurorestoration; TISSUE-PLASMINOGEN ACTIVATOR; EXOSOME-MEDIATED TRANSFER; Science & Technology; NEURAL PROGENITOR CELLS; PROMOTE FUNCTIONAL RECOVERY; Neurosciences & Neurology
• Research Categories: Biology, Neuroscience; Health Sciences, Medicine and Surgery

Abstract

Cell therapy is emerging as a viable therapy to restore neurological function after stroke. Many types of stem/progenitor cells from different sources have been explored for their feasibility and efficacy for the treatment of stroke. Transplanted cells not only have the potential to replace the lost circuitry, but also produce growth and trophic factors, or stimulate the release of such factors from host brain cells, thereby enhancing endogenous brain repair processes. Although stem/progenitor cells have shown a promising role in ischemic stroke in experimental studies as well as initial clinical pilot studies, cellular therapy is still at an early stage in humans. Many critical issues need to be addressed including the therapeutic time window, cell type selection, delivery route, and in vivo monitoring of their migration pattern. This review attempts to provide a comprehensive synopsis of preclinical evidence and clinical experience of various donor cell types, their restorative mechanisms, delivery routes, imaging strategies, future prospects and challenges for translating cell therapies as a neurorestorative regimen in clinical applications.