Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study

• Type of Material: Article
• Authors: Mathilde His, International Agency for Research on Cancer, Lyon; Carine Biessy, International Agency for Research on Cancer, Lyon; Gabriela Torres-Mejia, National Institute of Public Health, Mexico; Angelica Angeles-Llerenas, National Institute of Public Health, Mexico; Isabel Alvarado-Cabrero, Instituto Mexicano del Seguro Social; Gloria Ines Sanchez, University of Antioquia; Mauricio Borrero, University of Antioquia; Carolina Porras, Agencia Costarricense de Investigaciones Biomédicas (ACIB)-Fundación INCIENSA; Ana Cecilia Rodriguez, Agencia Costarricense de Investigaciones Biomédicas (ACIB)-Fundación INCIENSA; Maria Luisa Garmendia, Universidad de Chile; Magali Olivier, International Agency for Research on Cancer, Lyon; Peggy L. Porter, Fred Hutchinson Cancer Research Center; MingGang Lin, Fred Hutchinson Cancer Research Center, Seattle; Marc J. Gunter, International Agency for Research on Cancer, Lyon; Isabelle Romieu, Emory University; Sabina Rinaldi, International Agency for Research on Cancer, Lyon
• Language: English
• Date: 2020-02-10
• Publisher: Nature Publishing Group
• Publication Version: Final Published Version
• Copyright Statement: Copyright © The Author(s) 2020
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1038/s41598-020-59056-6
• Title of Journal or Parent Work: Scientific Reports
• Volume: 10
• Grant/Funding Information: The study is funded by the International Agency for Research on Cancer (IARC), the Union for International Cancer Control (UICC), the Pan American Health Organization (PAHO), the Ibero-American Programme for the Development of Science and Technology (CYTED), COLCIENCIAS (grant n°1115–569–348899), Universidad de Antioquia (grants CPT-1801, SIIU-2019–25272 and Estrategia de Sostenibilidad 2013–2014 to Group Infection and Cancer).; For MH, the work reported in this paper was undertaken during the tenure of a postdoctoral fellowship awarded by the International Agency for Research on Cancer, financed by La Ligue contre le cancer.
• Keywords: breast cancer; cancer prevention; risk factors; cancer epidemiology
• Research Categories: Health Sciences, Oncology

Abstract

Cumulating evidence in Caucasian women suggests a positive association between height and premenopausal breast cancer risk and a negative association with overall adiposity; however data from Latin America are scarce. We investigated the associations between excess adiposity, body shape evolution across life, and risk of premenopausal breast cancer among 406 cases (women aged 20–45) and 406 matched population-based controls from Chile, Colombia, Costa Rica, and Mexico. Negative associations between adult adiposity and breast cancer risk were observed in adjusted models (body mass index (BMI): Odds ratio (OR) per 1 kg/m2 = 0.93; 95% confidence interval = 0.89–0.96; waist circumference (WC): OR per 10 cm = 0.81 (0.69–0.96); hip circumference (HC): OR per 10 cm = 0.80 (0.67–0.95)). Height and leg length were not associated with risk. In normal weight women (18.5 ≤ BMI < 25), women with central obesity (WC > 88 cm) had an increased risk compared to women with normal WC (OR = 3.60(1.47–8.79)). Residuals of WC over BMI showed positive associations when adjusted for BMI (OR per 10 cm = 1.38 (0.98–1.94)). Body shape at younger ages and body shape evolution were not associated with risk. No heterogeneity was observed by receptor status. In this population of Latin American premenopausal women, different fat distributions in adulthood were differentially associated with risk of breast cancer.