Correlates of recovery of social functioning in type I and II bipolar disorder patients

• Type of Material: Article
• Authors: Aliza Wingo, Emory University; Ross J. Baldessarini, Harvard University; Michael T. Compton, Emory University; Philip D. Harvey, Emory University
• Language: English
• Date: 2010-05-15
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2010 Elsevier Ireland Ltd. All rights reserved.
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1016/j.psychres.2010.02.020
• Title of Journal or Parent Work: Psychiatry Research
• ISSN: 0165-1781
• Volume: 177
• Issue: 1-2
• Start Page: 131
• End Page: 134
• Grant/Funding Information: Dr. Harvey has current research support from AstraZeneca.; Supported by NIH grant UL1 RR-025008 and an APIRE research fellowship from the American Psychiatric Institute for Research & Education (to APW), a grant from the Bruce J. Anderson Foundation and the McLean Private Donors Research Fund (to RJB).
• Keywords: depression; age; neurocognition; social functional recovery; bipolar disorder
• Research Categories: Psychology, General

Abstract

Since bipolar disorder (BPD) patients are often functionally impaired, and factors associated with recovery from disability are largely unknown, we investigated demographic, clinical, and neurocognitive correlates of current social functional recovery in 65 stable participants diagnosed with DSM-IV type I (n=42) or II (n=23) BPD. Regaining highest previous levels of social functioning was rated with the Interpersonal Relationships Questionnaire. We also considered neuropsychological test findings as well as demographic and clinical information including mania and depression symptom-ratings. We examined factors associated with social recovery status using univariate analyses and then multiple logistic regression modeling. Of all subjects, 30 (46%) achieved current social functional recovery and 35 (54%) did not. Younger age (p=0.005) and lesser current depressive symptoms (p=0.02) were associated with social functional recovery, even after controlling for time since the last major mood episode, diagnostic type (II vs. I), co-morbid psychiatric illness, and executive functioning status. The findings are consistent with deleterious effects of even residual depressive symptoms in BPD patients.