Mesenchymal stromal cells for bone trauma, defects, and disease: Considerations for manufacturing, clinical translation, and effective treatments

• Type of Material: Article
• Authors: Annie C Bowles-Welch, Georgia Institute of Technology; Angela C Jimenez, Georgia Institute of Technology; Hazel Y Switchenko, Emory University; David A Romancik, Emory University; Linda E Kippner, Georgia Institute of Technology; Carolyn Yeago, Georgia Institute of Technology; Krishnendu Roy, Emory University
• Language: English
• Date: 2023-06-01
• Publisher: Elsevier Inc
• Publication Version: Final Published Version
• Copyright Statement: . © 2024 Elsevier B.V
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.bonr.2023.101656
• Title of Journal or Parent Work: Bone Reports
• Volume: 18
• Start Page: 101656
• End Page: 101656
• Keywords: Mesenchymal stromal cells; Bone disease; Bone trauma; Biomanufacturing; Bone defects; Cell therapy
• Research Categories: Biology, Cell; Engineering, Biomedical

Abstract

Bone is a complex tissue capable of natural repair to injury, however, the healing process is often impaired by the untoward effects of trauma, defects, and disease. Thus, therapeutic modalities, including the use of cells involved in the body's natural healing processes, are investigated to promote or complement natural bone repair. Herein, several modalities and innovative approaches for using mesenchymal stromal cells (MSCs) to treat bone trauma, defects, and diseases are discussed. Given the evidence that supports the promising potential of MSCs, we highlight important considerations for advancing the clinical use of MSCs including the standardization of procedures from the harvest to delivery to patients and realized solutions to manufacturing. A better understanding of the current approaches implemented to address the challenges of using therapeutic MSCs will help improve study designs and, ultimately, achieve effective outcomes for restoring bone health.