AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4

• Type of Material: Article
• Authors: Anapatricia Garcia, Emory University; Nagadenahalli B. Siddappa, Dana-Farber Cancer Institute; Qingsheng Li, University of Minnesota; Ashley T. Haase, University of Minnesota; Katherine Paul, Centers for Disease Control and Prevention; Fawn C Connor-Stroud, Emory University; Xiaodong Zhang, Emory University; A Jack Fountain Jr., Emory University; Francois Villinger, Emory University; Francis J. Novembre, Emory University; James Else, Emory University; W. Evan Secor, Centers for Disease Control and Prevention; Ruth M. Ruprecht, Dana-Farber Cancer Institute
• Language: English
• Date: 2010-10
• Publisher: Wiley: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2010 John Wiley & Sons A/S
• Final Published Version (URL): http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0684.2010.00416.x/abstract
• Title of Journal or Parent Work: Journal of Medical Primatology
• ISSN: 0047-2565
• Volume: 39
• Issue: 5
• Start Page: 356
• End Page: 360
• Grant/Funding Information: The work was supported by NIH grants R56 AI062515 to R.M.R., PO1 AI 048240 to R.M.R. and J.G.E., and base grant RR-000165 to the Yerkes National Primate Research Center.
• Keywords: R5 SHIV; neuroAIDS; optic neuropathy
• Research Categories: Health Sciences, Pathology

Abstract

A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4+ T cells to <200 cells/μl, opportunistic infections, coagulopathy and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy, and a focus of infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.