Spatial attention enhances network, cellular and subthreshold responses in mouse visual cortex

• Type of Material: Article
• Authors: Anderson Speed, Georgia Institute of Technology; Joseph Del Rosario, Georgia Institute of Technology; Navid Mikail, Georgia Institute of Technology; Bilal Haider, Emory University
• Language: English
• Date: 2020-01-24
• Publisher: Nature Publishing Group
• Publication Version: Final Published Version
• Copyright Statement: © 2020, The Author(s).
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1038/s41467-020-14355-4
• Title of Journal or Parent Work: Nature Communications
• Volume: 11
• Issue: 1
• Start Page: 505
• End Page: 505
• Grant/Funding Information: B.H. was funded by the Whitehall Foundation, Sloan Foundation, GT Neural Engineering Center, NIH NINDS (1R01NS107968), and NIH BRAIN Initiative (1R01NS109978); J.D.R. was funded by Goizueta Foundation and Sloan Foundation
• Keywords: BARREL CORTEX; STATES; GAIN MODULATION; V1; SELECTIVE ATTENTION; Science & Technology; NEURAL MECHANISMS; SENSITIVITY; SYNCHRONIZATION; Multidisciplinary Sciences; Science & Technology - Other Topics; REPRESENTATIONS; FLUCTUATIONS
• Research Categories: Biology, Neuroscience; Engineering, Biomedical

Abstract

Internal brain states strongly modulate sensory processing during behaviour. Studies of visual processing in primates show that attention to space selectively improves behavioural and neural responses to stimuli at the attended locations. Here we develop a visual spatial task for mice that elicits behavioural improvements consistent with the effects of spatial attention, and simultaneously measure network, cellular, and subthreshold activity in primary visual cortex. During trial-by-trial behavioural improvements, local field potential (LFP) responses to stimuli detected inside the receptive field (RF) strengthen. Moreover, detection inside the RF selectively enhances excitatory and inhibitory neuron responses to task-irrelevant stimuli and suppresses noise correlations and low frequency LFP fluctuations. Whole-cell patch-clamp recordings reveal that detection inside the RF increases synaptic activity that depolarizes membrane potential responses at the behaviorally relevant location. Our study establishes that mice display fundamental signatures of visual spatial attention spanning behavioral, network, cellular, and synaptic levels, providing new insight into rapid cognitive enhancement of sensory signals in visual cortex.