Microtubule-Associated Protein Mdp3 Promotes Breast Cancer Growth and Metastasis

• Type of Material: Article
• Authors: Tara ., Nankai University; Songbo Xie, Nankai University; Xiaodong Sun, Emory University; Xiaoou Sun, Nankai University; Jie Ran, Nankai University; Linlin Zhang, Nankai University; Dengwen Li, Nankai University; Min Liu, Nankai University; Gang Bao, Emory University; Jun Zhou, Emory University
• Language: English
• Date: 2014-01-01
• Publisher: Ivyspring International Publisher
• Publication Version: Final Published Version
• Copyright Statement: © Ivyspring International Publisher. CC BY NC 4.0
• Final Published Version (URL): http://dx.doi.org/10.7150/thno.9727
• Title of Journal or Parent Work: Theranostics
• ISSN: 1838-7640
• Volume: 4
• Issue: 10
• Start Page: 1052
• End Page: 1061
• Grant/Funding Information: This work was supported by the National Basic Research Program of China (2012CB945002 to JZ); the National Natural Science Foundation of China (31130015 to JZ, 31271437 to ML, and 31371382 to DL); the 111 project of the Ministry of Education of China (B08011 to JZ); and the US National Science Foundation as Science and Technology Center Grant (CBET-0939511 to GB).
• Keywords: growth; cell proliferation; cell motility; Medicine, Research & Experimental; breast cancer; Science & Technology; CENTROSOME AMPLIFICATION; Research & Experimental Medicine; metastasis; GAMMA-TUBULIN; Life Sciences & Biomedicine; EG5; SPINDLE MULTIPOLARITY; BINDING PROTEIN; EB1; PACLITAXEL SENSITIVITY; DYNAMICS; BRCA1
• Research Categories: Engineering, Biomedical

Abstract

Breast cancer is the most prevalent cancer in women worldwide with a high mortality rate, and the identification of new biomarkers and targets for this disease is greatly needed. Here we present evidence that microtubule-associated protein (MAP) 7 domain-containing protein 3 (Mdp3) is highly expressed in clinical samples and cell lines of breast cancer. The expression of Mdp3 correlates with clinicopathological parameters indicating breast cancer malignancy. In addition, Mdp3 promotes breast cancer cell proliferation and motility in vitro and stimulates breast cancer growth and metastasis in mice. Mechanistic studies reveal that ?-tubulin interacts with and recruits Mdp3 to the centrosome and that the centrosomal localization of Mdp3 is required for its activity to promote breast cancer cell proliferation and motility. These findings suggest a critical role for Mdp3 in the growth and metastasis of breast cancer and may have important implications for the management of this disease.