Publication

Considerations for resting state functional MRI and functional connectivity studies in rodents

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Last modified
  • 02/20/2025
Type of Material
Authors
    Wenju Pan, Emory UniversityJacob C. W. Billings, Emory UniversityJoshua K. Grooms, Georgia Institute of TechnologySadia Shakil, Georgia Institute of TechnologyShella Keilholz, Emory University
Language
  • English
Date
  • 2015-01-01
Publisher
  • Frontiers
Publication Version
Copyright Statement
  • © 2015 Pan, Billings, Grooms, Shakil and Keilholz.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1662-4548
Volume
  • 9
Issue
  • JUL
Grant/Funding Information
  • This work was supported by NIH R01 NS078095 and NIH R21 NS072810.
Abstract
  • Resting state functional MRI (rs-fMRI) and functional connectivity mapping have become widely used tools in the human neuroimaging community and their use is rapidly spreading into the realm of rodent research as well. One of the many attractive features of rs-fMRI is that it is readily translatable from humans to animals and back again. Changes in functional connectivity observed in human studies can be followed by more invasive animal experiments to determine the neurophysiological basis for the alterations, while exploratory work in animal models can identify possible biomarkers for further investigation in human studies. These types of interwoven human and animal experiments have a potentially large impact on neuroscience and clinical practice. However, impediments exist to the optimal application of rs-fMRI in small animals, some similar to those encountered in humans and some quite different. In this review we identify the most prominent of these barriers, discuss differences between rs-fMRI in rodents and in humans, highlight best practices for animal studies, and review selected applications of rs-fMRI in rodents. Our goal is to facilitate the integration of human and animal work to the benefit of both fields.
Author Notes
Keywords
Research Categories
  • Biology, Neuroscience
  • Health Sciences, General

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