Prospective associations of plasma phospholipids and mild cognitive impairment/dementia among African Americans in the ARIC Neurocognitive Study

• Type of Material: Article
• Authors: Danni Li, University of Minnesota; Jeffrey R. Misialek, University of Minnesota; Eric Boerwinkle, University of Texas; Rebecca F. Gottesman, Johns Hopkins University; A. Richey Sharrett, Johns Hopkins University; Thomas H. Mosley, University of Mississippi; Josef Coresh, Johns Hopkins University; Lisa M. Wruck, University of North Carolina; David S. Knopman, Mayo Clinic; Alvaro Alonso, Emory University
• Language: English
• Date: 2017-01-01
• Publisher: Elsevier
• Publication Version: Final Published Version
• Copyright Statement: © 2016 The Authors.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.dadm.2016.09.003
• Title of Journal or Parent Work: Alzheimer's and Dementia
• ISSN: 1552-5260
• Volume: 6
• Start Page: 1
• End Page: 10
• Grant/Funding Information: The Atherosclerosis Risk in Community (ARIC) Study is carried out as a collaborative study supported by the National Heart, Lung, and Blood Institute contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN2682011000010C, HHSN2682011000011C, and HHSN2682011000012C).; Neurocognitive data are collected by the support of the National Heart, Lung, and Blood Institute U01 HL096812, HL096814, HL096899, HL096902, and HL096917 with previous brain MRI examinations funded by R01-HL70825.
• Keywords: Mild cognitive impairment; Alzheimer's disease; AD; ARIC; Plasma; MCI; ARIC-NCS; Metabolites; Dementia; Phospholipids; Metabolomics
• Research Categories: Health Sciences, Epidemiology; Biology, Neuroscience

Abstract

Introduction: The objective of this study was to investigate whether 10 phospholipids/metabolites previously identified as prospectively predictive of mild cognitive impairment (MCI) or dementia in whites would also be predictive in a mostly African-American cohort. Methods: We repeatedly measured 188 phospholipids/metabolites in plasma samples of 221 participants of the Atherosclerosis Risk in Communities study, 97% African American, who were followed between 2004–2006 and 2011–2013. Results: After a mean follow-up of 7.3 years, 77 were classified as having MCI and 18 as having dementia. Our study failed to replicate previous findings in this mostly African American cohort, in that the 10 phospholipids/metabolites only achieved a C statistic/AUC of 0.609 in predicting development of MCI or dementia (compared to 0.96) and 0.607 in distinguishing normal from MCI or dementia at the follow-up visit. Conclusion: A panel of 10 phospholipids/metabolites previously associated with incident dementia was not predictive of MCI or dementia in an independent cohort.