Racial/Ethnic Differences in Infant Mortality Attributable to Birth Defects by Gestational Age

• Type of Material: Article
• Authors: Cheryl S. Broussard, Centers for Disease Control and Prevention; Suzanne M. Gilboa, Centers for Disease Control and Prevention; Kyung A. Lee, Centers for Disease Control and Prevention; Matthew Oster, Emory University; Joann R. Petrini, Danbury Hospital; Margaret A. Honein, Centers for Disease Control and Prevention
• Language: English
• Date: 2012-09-01
• Publisher: American Academy of Pediatrics
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: Copyright © 2012 by the American Academy of Pediatrics.
• Final Published Version (URL): http://dx.doi.org/10.1542/peds.2011-3475
• Title of Journal or Parent Work: Pediatrics
• ISSN: 0031-4005
• Volume: 130
• Issue: 3
• Start Page: E518
• End Page: E527
• Grant/Funding Information: This research was supported in part by an appointment to the Research Participation Program at the Centers for Disease Control and Prevention, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC.
• Keywords: ethnicity; UNITED-STATES; birth defects; WOMEN; race; Pediatrics; infant mortality; DOWN-SYNDROME; CALIFORNIA; Life Sciences & Biomedicine; PREVALENCE; PREGNANCY; Science & Technology; gestational age; METROPOLITAN ATLANTA
• Research Categories: Health Sciences, Medicine and Surgery; Health Sciences, Human Development

Abstract

OBJECTIVE: Birth defects are a leading cause of infant mortality in the United States. Previous reports have highlighted black-white differences in overall infant mortality and infant mortality attributable to birth defects (IMBD). We evaluated the impact of gestational age on US racial/ethnic differences in IMBD. METHODS: We estimated the rate of IMBD as the underlying cause of death using the period-linked birth/infant death data for US residents for January 2003 to December 2006. We excluded infants with missing gestational age, implausible values based on Alexander 's index of birth weight for gestational age norms, or gestational ages <20 weeks or >44 weeks; we categorized gestational age into 3 groups: 20 to 33, 34 to 36, and 37 to 44 weeks. Using Poisson regression, we compared neonatal and postneonatal IMBD for infants of non-Hispanic black and Hispanic mothers with that for infants of non-Hispanic white mothers stratified by gestational age. RESULTS: IMBD occurred in 12.2 per 10 000 live births. Among infants delivered at 37 to 44 weeks, blacks (and Hispanics, to a lesser degree) had significantly higher neonatal and postneonatal IMBD than whites; however, among infants delivered at 20 to 33 or 34 to 36 weeks, neonatal (but not postneonatal) IMBD was significantly lower among blacks compared with whites. CONCLUSIONS: Racial/ethnic differences in IMBD were not explained in these data by differences in gestational age. Further investigation should include an assessment of possible racial/ethnic differences in severity and/or access to timely diagnosis and management of birth defects.