Oncogenic human papillomavirus genital infection in southern Iranian women: population-based study versus clinic-based data

• Type of Material: Article
• Authors: Seyed Sajjad Eghbali, Bushehr University of Medical Sciences; Roya Amirinejad, Bushehr University of Medical Sciences; Narges Obeidi, Bushehr University of Medical Sciences; Shiva Mosadeghzadeh, Bushehr University of Medical Sciences; Katayou Vahdat, Bushehr University of Medical Sciences; Fatemeh Azizi, Bushehr University of Medical Sciences; Raha Pazoki, Bushehr University of Medical Sciences; Zahra Sanjdideh, Bushehr University of Medical Sciences; Zahra Amiri, Bushehr University of Medical Sciences; Iraj Nabipour, Bushehr University of Medical Sciences; Keivan Zandi, Emory University
• Language: English
• Date: 2012-09-12
• Publisher: BioMed Central
• Publication Version: Final Published Version
• Copyright Statement: © 2012 Eghbali et al.; licensee BioMed Central Ltd.
• License: Creative Commons Attribution 2.0 Generic
• Final Published Version (URL): http://dx.doi.org/10.1186/1743-422X-9-194
• Title of Journal or Parent Work: Virology Journal
• ISSN: 1743-422X
• Volume: 9
• Issue: 1
• Start Page: 194
• End Page: 194
• Grant/Funding Information: This study was supported in part by a grant from the Bushehr Province Technology and Research Committee and the Research Deputy of Bushehr University of Medical Science.
• Keywords: PCR; CERVICAL-CANCER WORLDWIDE; SMEAR; METAANALYSIS; Iran; Cervical cancer; TEHRAN; PREVALENCE; HPV TYPES; Human papilloma virus; Life Sciences & Biomedicine; Virology; Science & Technology; CYTOLOGY; Bushehr

Abstract

Background: Epidemiological studies on genital human papilloma viruses infection (HPVs) in general population are crucial for the implementation of health policy guidelines for developing the strategies to prevent the primary and secondary cervical cancer. In different parts of Iran, there is a lack of population-based studies to determine the prevalence of HPV in the general population. The aim of this population-based study is to compare the prevalence rate of genital HPV infection among reproductive women with our previous clinic-based data, which showed a prevalence rate of 5% in women in southern Iran. Results: Using general primers for all genotypes of HPV, of 799 randomly selected women, five (0.63%, 95% CI 0.23-1.55%) tested positive for HPV DNA. Overall, seven different HPV genotypes were detected: six types (16, 18, 31, 33, 51 and 56) were carcinogenic, or "high risk genotypes" and one genotype (HPV-66) was "probably carcinogenic." Conclusions: In a population-based study, the prevalence of HPV infection among southern Iranian women was lower than that observed worldwide. However, our gynaecological clinic-based study on the prevalence of HPV infection showed results comparable with other studies in the Middle East and Persian Gulf countries. Since gynaecological clinic-based data may generally overestimate HPV prevalence, estimates of prevalence according to clinic-based data should be adjusted downward by the population-based survey estimates.