Reconstructing Organophosphorus Pesticide Doses Using the Reversed Dosimetry Approach in a Simple Physiologically-Based Pharmacokinetic Model

• Type of Material: Article
• Authors: Chensheng Lu, Emory University; Leo Andres, Atlanta Clinical and Translational Science Institute
• Language: English
• Date: 2012
• Publisher: Hindawi Publishing Corporation
• Publication Version: Final Published Version
• Copyright Statement: © 2012 C. Lu and L. Andres
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1155/2012/131854
• Title of Journal or Parent Work: Journal of Toxicology
• Volume: 2012
• Start Page: 1
• End Page: 8
• Grant/Funding Information: This work was supported by the U.S. Environmental Protection Agency under the Science to Achieve Results research assistance program (R-832244 and R-829364)
• Keywords: Toxicology; urinary biomarkers; Pesticide; PBPK model
• Research Categories: Health Sciences, General; Health Sciences, Public Health

Abstract

We illustrated the development of a simple pharmacokinetic (SPK) model aiming to estimate the absorbed chlorpyrifos doses using urinary biomarker data, 3,5,6-trichlorpyridinol as the model input. The effectiveness of the SPK model in the pesticide risk assessment was evaluated by comparing dose estimates using different urinary composite data. The dose estimates resulting from the first morning voids appeared to be lower than but not significantly different to those using before bedtime, lunch or dinner voids. We found similar trend for dose estimates using three different urinary composite data. However, the dose estimates using the SPK model for individual children were significantly higher than those from the conventional physiologically based pharmacokinetic (PBPK) modeling using aggregate environmental measurements of chlorpyrifos as the model inputs. The use of urinary data in the SPK model intuitively provided a plausible alternative to the conventional PBPK model in reconstructing the absorbed chlorpyrifos dose.