Publication

Growth Inhibitory Activity of Callicarpa americana Leaf Extracts Against Cutibacterium acnes

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Last modified
  • 05/14/2025
Type of Material
Authors
    Rozenn M Pineau, Georgia Institute of TechnologySarah E Hanson, Emory UniversityJames T Lyles, Emory UniversityCassandra Quave, Emory University
Language
  • English
Date
  • 2019-10-15
Publisher
  • Frontiers Media SA
Publication Version
Copyright Statement
  • © 2019 Pineau, Hanson, Lyles and Quave.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 10
Start Page
  • 1206
End Page
  • 1206
Grant/Funding Information
  • This work was supported by faculty development funds from the Emory University School of Medicine, Department of Dermatology and Emory College of Arts and Sciences, Center for the Study of Human Health.
Abstract
  • Acne vulgaris is a common skin disease affecting adolescents and young adults of all ethnic groups, negatively impacting self-esteem, self-confidence, and social life. The Gram-positive bacteria Cutibacterium acnes colonizes the sebum-rich follicle and contributes to inflammation of the pilosebaceous gland. Long-term antibiotic therapies targeting C. acnes lead to the development of antimicrobial resistance, and novel acne vulgaris therapies are needed. This study investigated the C. acnes inhibitory activity of Callicarpa americana leaves, a native Southeastern United States shrub historically used by Native Americans to treat fever, stomachache, and pruritis. Flash chromatography fractions of the ethyl acetate-soluble C. americana ethanol leaf extract (649C-F9 and 649C-F13) exhibited MICs ranging from 16 to 32 µg ml−1 and IC50 range of 4-32 μg ml−1 against a panel of 10 distinct C. acnes isolates. Cytotoxicity against an immortalized human keratinocyte cell line (HaCaTs) skin was detected at more than eight times the dose required for growth inhibitory activity (IC50 of 256 μg ml−1 for 649C-F9 and IC50 of >512 μg ml−1 for 649C-F13). This work highlights the potential of C. americana leaf extracts as a cosmeceutical ingredient for the management of acne vulgaris. Further research is necessary to assess its mechanism of action and in vivo efficacy.
Author Notes
Keywords
Research Categories
  • Health Sciences, General
  • Health Sciences, Medicine and Surgery

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