Publication

Epigenetic Regulations in Neuropsychiatric Disorders

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Last modified
  • 05/15/2025
Type of Material
Authors
    Janise N. Kuehner, Emory UniversityEmily C. Bruggeman, Emory UniversityZhexing Wen, Emory UniversityBing Yao, Emory University
Language
  • English
Date
  • 2019-04-04
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2019 Kuehner, Bruggeman, Wen and Yao.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-8021
Volume
  • 10
Start Page
  • 268
End Page
  • 268
Abstract
  • Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for proper brain development, function and circuitry formation in the mammalian central nervous system. Neuronal differentiation processes are tightly regulated by epigenetic mechanisms including DNA methylation, histone modifications, chromatin remodelers and non-coding RNAs. Dysregulation of any of these pathways is detrimental to normal neuronal development and functions, which can result in devastating neuropsychiatric disorders, such as depression, schizophrenia and autism spectrum disorders. In this review, we focus on the current understanding of epigenetic regulations in brain development and functions, as well as their implications in neuropsychiatric disorders.
Author Notes
Keywords
Research Categories
  • Health Sciences, Mental Health
  • Biology, Neuroscience
  • Biology, Genetics

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