Programmed T cell differentiation: Implications for transplantation

• Type of Material: Article
• Authors: Rebecca L Crepeau, Emory University; Mandy Ford, Emory University
• Language: English
• Date: 2020-05-01
• Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2020 Elsevier Inc. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.cellimm.2020.104099
• Title of Journal or Parent Work: CELLULAR IMMUNOLOGY
• Volume: 351
• Start Page: 104099
• End Page: 104099
• Keywords: IFN-GAMMA; Tissue-resident memory; Life Sciences & Biomedicine; GRAFT-REJECTION; Immunology; IN-VIVO; Trm; Transplantation; Eomes; T cell differentiation; Science & Technology; RENAL-TRANSPLANTATION; TRANSCRIPTION FACTOR IRF4; REGULATORY FACTOR 4; IRF4; FOLLICULAR HELPER; Tbet; ALLOGRAFT-REJECTION; Transcriptional regulation; CUTTING EDGE; Cell Biology; PASSENGER LEUKOCYTES

Abstract

While T cells play a critical role in protective immunity against infection, they are also responsible for graft rejection in the setting of transplantation. T cell differentiation is regulated by both intrinsic transcriptional pathways as well as extrinsic factors such as antigen encounter and the cytokine milieu. Herein, we review recent discoveries in the transcriptional regulation of T cell differentiation and their impact on the field of transplantation. Recent studies uncovering context-dependent differentiation programs that differ in the setting of infection or transplantation will also be discussed. Understanding the key transcriptional pathways that underlie T cell responses in transplantation has important clinical implications, including development of novel therapeutic agents to mitigate graft rejection.