Comprehensive primary prevention of cardiovascular disease in women

• Type of Material: Article
• Authors: Suegene K. Lee, Emory University; Jay Khambhati, Emory University; Tina Varghese, Emory University; Eric P. Stahl, Emory University; Sonali Kumar, Emory University; Pratik B. Sandesara, Emory University; Nanette K Wenger, Emory University; Laurence S Sperling, Emory University
• Language: English
• Date: 2017-10-01
• Publisher: Wiley Open Access: Various Creative Commons Licenses
• Publication Version: Final Published Version
• Copyright Statement: © 2017 Wiley Periodicals, Inc.
• Final Published Version (URL): http://dx.doi.org/10.1002/clc.22767
• Title of Journal or Parent Work: Clinical Cardiology
• ISSN: 0160-9289
• Volume: 40
• Issue: 10
• Start Page: 832
• End Page: 838
• Keywords: AGE; RANDOMIZED-TRIAL; CORONARY-HEART-DISEASE; Cardiac & Cardiovascular Systems; Disparities; HEALTH; Prevention; Women; Life Sciences & Biomedicine; GENDER; RISK-FACTORS; STROKE; MYOCARDIAL-INFARCTION; Cardiovascular System & Cardiology; LOW-DOSE ASPIRIN; EVENTS; Science & Technology; Cardiovascular Disease
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality in women. Historically, medical research has focused on male patients, and subsequently, there has been decreased awareness of the burden of ASCVD in females until recent years. The biological differences between sexes and differences in societal expectations defined by gender roles contribute to gender differences in ASCVD risk factors. With these differing risk profiles, risk assessment, risk stratification, and primary preventive measures of ASCVD are different in women and men. In this review article, clinicians will understand the risk factors unique to women, such as preeclampsia, gestational diabetes, and those that disproportionately affect them such as autoimmune disorders. With these conditions in mind, the approach to ASCVD risk assessment and stratification in women will be discussed. Furthermore, the literature behind the effects of primary preventive measures in women, including lifestyle modifications, aspirin, statins, and anticoagulation, will be reviewed. The aim of this review article was to ultimately improve ASCVD primary prevention by reducing gender disparities through education of physicians.